Reaction Details Report a problem with these data
Target
3-hydroxyacyl-CoA dehydrogenase type-2
Ligand
BDBM50466363
Substrate
n/a
Meas. Tech.
ChEMBL_1792852 (CHEMBL4264771)
IC50
610000±n/a nM
Citation
 Boutin, S; Roy, J; Maltais, R; Alata, W; Calon, F; Poirier, D Identification of steroidal derivatives inhibiting the transformations of allopregnanolone and estradiol by 17?-hydroxysteroid dehydrogenase type 10. Bioorg Med Chem Lett 28:3554-3559 (2018) [PubMed]  Article 
Target
Name:
3-hydroxyacyl-CoA dehydrogenase type-2
Synonyms:
1.1.1.178 | 1.1.1.35 | 1.1.1.51 | 17-beta-HSD 10 | 17-beta-hydroxysteroid dehydrogenase 10 | 3-hydroxy-2-methylbutyryl-CoA dehydrogenase | 3-hydroxyacyl-CoA dehydrogenase type II | 3-hydroxyacyl-CoA dehydrogenase type-2 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Erab | HCD2_MOUSE | Hadh2 | Hsd17b10 | Mitochondrial RNase P protein 2 | Mitochondrial ribonuclease P protein 2 | Type II HADH
Type:
PROTEIN
Mol. Mass.:
27421.83
Organism:
Mus musculus
Description:
ChEMBL_117895
Residue:
261
Sequence:
MAAAVRSVKGLVAVVTGGASGPWLATAKRLVGQGATAVLLDVPDSEGESQAKKLGESCIFAPANVTSEKEIQAALTLAKEKFGRIDVAVNCAGIAVAIKTYHQKKNKIHTLEDFQRVINVNLIGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIDGMTLPIARDLAPTGIRVVTIAPGLFATPLLTTLPEKVRNFLASQVPFPSRLGDPAEYAHLVQTIIENPFLNGEVIRLDGAIRMQP
  
Inhibitor
Name:
BDBM50466363
Synonyms:
CHEMBL4277154
Type:
Small organic molecule
Emp. Form.:
C32H50N2O3
Mol. Mass.:
510.751
SMILES:
[H][C@@]12CC[C@@H](O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])C[C@@](O)(CN3CCN(Cc4cccc(OC)c4)CC3)CC[C@]12C |r|
Structure:
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