Affinity DataKi: 3nM ΔG°: -50.6kJ/molepH: 7.5 T: 2°CAssay Description:For steady-state kinetic study of hybrid inhibitors, a Fluorolog 3 instrument was used to monitor the fluorescent signal of NADPH formed during estra...More data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Inhibition of (unknown origin) 17beta-HSD1 assessed as conversion of [14C]estradiol to [14C]estrone using NADP+More data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Inhibition of human liver microsomes CYP1B1 expressed in baculovirus infected insect cells coexpressing human NADPH-cytochrome P450 reductase using 7...More data for this Ligand-Target Pair
Affinity DataKi: 4.40nMAssay Description:Inhibition of recombinant CYP1B1 (unknown origin) expressed in supersomes coexpressing NADPH-CYP reductase using 7-ethoxyresorufin as substrate after...More data for this Ligand-Target Pair
Affinity DataKi: 7nMAssay Description:Inhibition of CYP1B1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 16nMAssay Description:Inhibition of recombinant human CYP1B1 expressed in Escherichia coli coexpressing human NADPH-cytochrome P450 reductase using 7-ethoxyresorufin as su...More data for this Ligand-Target Pair
Affinity DataKi: 16nMAssay Description:Inhibition of CYP1B1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 23nMAssay Description:Inhibition of CYP1B1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 27nMAssay Description:Inhibition of CYP1B1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 30nMAssay Description:Inhibition of recombinant CYP1B1 (unknown origin) expressed in supersomes coexpressing NADPH-CYP reductase using 7-ethoxyresorufin as substrate after...More data for this Ligand-Target Pair
Affinity DataKi: 35nMAssay Description:Inhibition of CYP1B1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Inhibition of recombinant CYP1B1 (unknown origin) expressed in supersomes coexpressing NADPH-CYP reductase using 7-ethoxyresorufin as substrate after...More data for this Ligand-Target Pair
Affinity DataKi: 44nMAssay Description:Inhibition of human CYP1B1 expressed in Escherichia coli DH5alpha coexpressing human NADPH-P450 reductase using 4-estradiol as substrate in presence ...More data for this Ligand-Target Pair
Affinity DataKi: 79nMAssay Description:Competitive inhibition of human liver microsomes CYP1A2 expressed in supersomes coexpressing NADPH-CYP reductase using 7-Ethoxyresorufin as substrate...More data for this Ligand-Target Pair
Affinity DataKi: 130nMAssay Description:Inhibition of recombinant human CYP1A1 expressed in supersomes coexpressing NADPH-CYP reductase using 7-ethoxyresorufin as substrate after 15 mins in...More data for this Ligand-Target Pair
Affinity DataKi: 148nMAssay Description:Competitive inhibition of human liver microsomes CYP1B1 expressed in supersomes coexpressing NADPH-CYP reductase using 7-Ethoxyresorufin as substrate...More data for this Ligand-Target Pair
Affinity DataKi: 150nMAssay Description:Competitive inhibition of human liver microsomes CYP1A1 expressed in supersomes coexpressing NADPH-CYP reductase using 7-Ethoxyresorufin as substrate...More data for this Ligand-Target Pair
Affinity DataKi: 160nMAssay Description:Inhibition of recombinant human CYP1A1 expressed in supersomes coexpressing NADPH-CYP reductase using 7-ethoxyresorufin as substrate after 15 mins in...More data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Inhibitory constant against human placenta 17-beta-hydroxysteroid dehydrogenase type 2 (17-beta-HSD type 2)More data for this Ligand-Target Pair
Affinity DataKi: 300nMAssay Description:Inhibition of human CYP1B1 expressed in Escherichia coli DH5alpha coexpressing human NADPH-P450 reductase using 4-estradiol as substrate in presence ...More data for this Ligand-Target Pair
Affinity DataKi: 500nMAssay Description:Inhibition of recombinant CYP1B1 (unknown origin) expressed in supersomes coexpressing NADPH-CYP reductase using 7-ethoxyresorufin as substrate after...More data for this Ligand-Target Pair
Affinity DataKi: 500nMAssay Description:Inhibition of recombinant human CYP1A2 expressed in Escherichia coli DH5alpha coexpressing human NADPH-cytochrome P450 reductase in using 7-ethoxyres...More data for this Ligand-Target Pair
Affinity DataKi: 500nMAssay Description:Inhibition of recombinant human CYP1B1 expressed in Escherichia coli coexpressing human NADPH-cytochrome P450 reductase using 7-ethoxyresorufin as su...More data for this Ligand-Target Pair
Affinity DataKi: 541nMAssay Description:Competitive inhibition of human liver microsomes CYP1A1 expressed in supersomes coexpressing NADPH-CYP reductase using 7-Ethoxyresorufin as substrate...More data for this Ligand-Target Pair
Affinity DataKi: 570nMAssay Description:Inhibition of recombinant human CYP1A1 expressed in supersomes coexpressing NADPH-CYP reductase using 7-ethoxyresorufin as substrate after 15 mins in...More data for this Ligand-Target Pair
Affinity DataKi: 700nMAssay Description:Inhibition of human CYP1B1 expressed in Escherichia coli DH5alpha coexpressing human NADPH P450 reductase using 7-ethoxyresorufin as substrate in pre...More data for this Ligand-Target Pair
Affinity DataKi: 800nMAssay Description:Inhibition of recombinant human CYP1B1 expressed in supersomes coexpressing NADPH-CYP reductase using 7-ethoxyresorufin as substrate after 15 mins in...More data for this Ligand-Target Pair
Affinity DataKi: 900nMAssay Description:Inhibition of recombinant human CYP1B1 expressed in supersomes coexpressing NADPH-CYP reductase using 7-ethoxyresorufin as substrate after 15 mins in...More data for this Ligand-Target Pair
Affinity DataKi: 910nMAssay Description:Inhibition of recombinant human CYP1B1 expressed in supersomes coexpressing NADPH-CYP reductase using 7-ethoxyresorufin as substrate after 15 mins in...More data for this Ligand-Target Pair
Affinity DataKi: 1.00E+3nMAssay Description:Competitive inhibition of CYP1B1 (unknown origin) expressed in yeast microsomes using (-)benzo[a]pyrene-7R-trans-7,8-dihyrodiol (B[a]P-7,8-diol) as s...More data for this Ligand-Target Pair
Affinity DataKi: 1.90E+3nMAssay Description:Inhibition of CYP1B1 in human liver microsomes coexpressing recombinant human cytochrome P450 oxidoreductase using 7-ethoxyresorufin as substrate aft...More data for this Ligand-Target Pair
Affinity DataKi: 1.90E+3nMAssay Description:Inhibition of human CYP1B1 expressed in supersomes using ethoxyresorufin as substrate after 20 mins in presence of NADP by Dixon plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 2.00E+3nMAssay Description:Inhibition of recombinant human CYP1B1 expressed in supersomes using ethoxyresorufin as substrate after 20 mins in presence of NADPH by fluorescence ...More data for this Ligand-Target Pair
Affinity DataKi: 2.06E+3nMAssay Description:Inhibition of recombinant human CYP1B1 expressed in supersomes coexpressing NADPH-CYP reductase using 7-ethoxyresorufin as substrate after 15 mins in...More data for this Ligand-Target Pair
Affinity DataKi: 2.30E+3nMAssay Description:Inhibition of CYP1B1 (unknown origin) expressed in Escherichia coli DH5alpha coexpressing human NADPH P450 reductase using 7-ethoxyresorufin as subst...More data for this Ligand-Target Pair
Affinity DataKi: 2.40E+3nMAssay Description:Inhibition of recombinant human CYP1A1 expressed in Escherichia coli DH5alpha coexpressing human NADPH-cytochrome P450 reductase in using 7-ethoxyres...More data for this Ligand-Target Pair
Affinity DataKi: 3.70E+3nMAssay Description:Inhibition of CYP1B1 in human liver microsomes coexpressing recombinant human cytochrome P450 oxidoreductase using 7-ethoxyresorufin as substrate aft...More data for this Ligand-Target Pair
Affinity DataKi: 6.00E+3nMAssay Description:Competitive inhibition of CYP1B1 (unknown origin) expressed in yeast microsomes using (-)benzo[a]pyrene-7R-trans-7,8-dihyrodiol (B[a]P-7,8-diol) as s...More data for this Ligand-Target Pair
Affinity DataKi: 1.10E+4nMAssay Description:Competitive inhibition of CYP1B1 (unknown origin) expressed in yeast microsomes using (-)benzo[a]pyrene-7R-trans-7,8-dihyrodiol (B[a]P-7,8-diol) as s...More data for this Ligand-Target Pair
Affinity DataKi: 1.12E+4nMAssay Description:Inhibition of CYP1B1 in TCDD-exposed human MCF-7 cells using ethoxyresorufin as substrate after 20 mins in presence of NADPH by Lineweaver-Burk linea...More data for this Ligand-Target Pair
Affinity DataKi: 1.20E+4nMAssay Description:Mixed type inhibition of human hepatic microsomes CYP1A2 expressed in supersomes coexpressing NADPH-cytochrome P450 reductase using 7-Ethoxyresorufin...More data for this Ligand-Target Pair
Affinity DataKi: 1.40E+4nMAssay Description:Mixed type inhibition of human hepatic microsomes CYP1B1 expressed in supersomes coexpressing NADPH-cytochrome P450 reductase using 7-Ethoxyresorufin...More data for this Ligand-Target Pair
Affinity DataKi: 2.80E+4nMAssay Description:Inhibition of recombinant CYP1B1 (unknown origin) expressed in Escherichia coli DH5alphaF'Iq coexpressing human NADPH-P450 reductase using E2-d4 as s...More data for this Ligand-Target Pair
Affinity DataKi: 3.60E+4nMAssay Description:Inhibition of recombinant CYP1B1 (unknown origin) expressed in Escherichia coli DH5alphaF'Iq coexpressing human NADPH-P450 reductase using E2-d4 as s...More data for this Ligand-Target Pair
Affinity DataKi: 5.90E+4nMAssay Description:Mixed type inhibition of human hepatic microsomes CYP1A1 expressed in supersomes coexpressing NADPH-cytochrome P450 reductase using 7-Ethoxyresorufin...More data for this Ligand-Target Pair
Affinity DataKi: 6.90E+4nMAssay Description:Inhibition of recombinant CYP1A1 (unknown origin) expressed in Escherichia coli DH5alphaF'Iq coexpressing human NADPH-P450 reductase using E2-d4 as s...More data for this Ligand-Target Pair
Affinity DataKi: 8.80E+4nMAssay Description:Inhibition of recombinant CYP1A1 (unknown origin) expressed in Escherichia coli DH5alphaF'Iq coexpressing human NADPH-P450 reductase using E2-d4 as s...More data for this Ligand-Target Pair
Affinity DataKi: 9.81E+4nMAssay Description:Inhibition of recombinant human C-terminal His-tagged UGT1A10 after 15 to 60 mins by Michaelis-Menten equation analysis in presence of UDPGAMore data for this Ligand-Target Pair
Affinity DataKi: 1.49E+5nMAssay Description:Inhibition of recombinant CYP1B1 (unknown origin) expressed in Escherichia coli DH5alphaF'Iq coexpressing human NADPH-P450 reductase using E2-d4 as s...More data for this Ligand-Target Pair
Affinity DataKi: 1.62E+5nMAssay Description:Inhibition of recombinant human C-terminal His-tagged UGT2B7 after 15 to 60 mins by Michaelis-Menten equation analysis in presence of UDPGAMore data for this Ligand-Target Pair