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Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50467045
Substrate
n/a
Meas. Tech.
ChEMBL_1794841 (CHEMBL4266958)
EC50
17±n/a nM
Citation
 Koshizawa, T; Morimoto, T; Watanabe, G; Fukuda, T; Yamasaki, N; Hagita, S; Sawada, Y; Okuda, A; Shibuya, K; Ohgiya, T Discovery of novel spiro[chromane-2,4'-piperidine] derivatives as potent and orally bioavailable G-protein-coupled receptor 119 agonists. Bioorg Med Chem Lett 28:3236-3241 (2018) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50467045
Synonyms:
CHEMBL4284899
Type:
Small organic molecule
Emp. Form.:
C30H28F6N2O5S
Mol. Mass.:
642.609
SMILES:
FC(F)(F)C(OC(=O)N1CCC2(CC1)CCc1cc(ccc1O2)-c1ccc(CS(=O)(=O)Cc2ccccn2)cc1)C(F)(F)F
Structure:
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