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Target
Dopamine beta-hydroxylase
Ligand
BDBM50025804
Substrate
n/a
Meas. Tech.
ChEMBL_59116 (CHEMBL667909)
IC50
49000±n/a nM
Citation
 Kruse, LI; Kaiser, C; DeWolf, WE; Frazee, JS; Ross, ST; Wawro, J; Wise, M; Flaim, KE; Sawyer, JL; Erickson, RW Multisubstrate inhibitors of dopamine beta-hydroxylase. 2. Structure-activity relationships at the phenethylamine binding site. J Med Chem 30:486-94 (1987) [PubMed]  Article 
Target
Name:
Dopamine beta-hydroxylase
Synonyms:
DBH | DOPO_BOVIN
Type:
PROTEIN
Mol. Mass.:
68136.39
Organism:
Bos taurus
Description:
ChEMBL_50738
Residue:
610
Sequence:
MQVPSPSVREAASMYGTAVAVFLVILVAALQGSAPAESPFPFHIPLDPEGTLELSWNISYAQETIYFQLLVRELKAGVLFGMSDRGELENADLVVLWTDRDGAYFGDAWSDQKGQVHLDSQQDYQLLRAQRTPEGLYLLFKRPFGTCDPNDYLIEDGTVHLVYGFLEEPLRSLESINTSGLHTGLQRVQLLKPSIPKPALPADTRTMEIRAPDVLIPGQQTTYWCYVTELPDGFPRHHIVMYEPIVTEGNEALVHHMEVFQCAAEFETIPHFSGPCDSKMKPQRLNFCRHVLAAWALGAKAFYYPEEAGLAFGGPGSSRFLRLEVHYHNPLVITGRRDSSGIRLYYTAALRRFDAGIMELGLAYTPVMAIPPQETAFVLTGYCTDKCTQLALPASGIHIFASQLHTHLTGRKVVTVLARDGRETEIVNRDNHYSPHFQEIRMLKKVVSVQPGDVLITSCTYNTEDRRLATVGGFGILEEMCVNYVHYYPQTQLELCKSAVDPGFLHKYFRLVNRFNSEEVCTCPQASVPEQFASVPWNSFNREVLKALYGFAPISMHCNRSSAVRFQGEWNRQPLPEIVSRLEEPTPHCPASQAQSPAGPTVLNISGGKG
  
Inhibitor
Name:
BDBM50025804
Synonyms:
1-(4-Hydroxy-3-methyl-benzyl)-1,3-dihydro-imidazole-2-thione | CHEMBL63767
Type:
Small organic molecule
Emp. Form.:
C11H12N2OS
Mol. Mass.:
220.291
SMILES:
Cc1cc(Cn2cc[nH]c2=S)ccc1O
Structure:
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