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Target
D-amino-acid oxidase
Ligand
BDBM50324678
Substrate
n/a
Meas. Tech.
ChEMBL_1796663 (CHEMBL4268780)
IC50
7800±n/a nM
Citation
 Kato, Y; Hin, N; Maita, N; Thomas, AG; Kurosawa, S; Rojas, C; Yorita, K; Slusher, BS; Fukui, K; Tsukamoto, T Structural basis for potent inhibition of d-amino acid oxidase by thiophene carboxylic acids. Eur J Med Chem 159:23-34 (2018) [PubMed]  Article 
Target
Name:
D-amino-acid oxidase
Synonyms:
D-amino-acid oxidase (DAAO) | DAAO | DAMOX | DAO | OXDA_HUMAN
Type:
Homodimer
Mol. Mass.:
39476.06
Organism:
Homo sapiens (Human)
Description:
P14920
Residue:
347
Sequence:
MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLSRMPPSHL
  
Inhibitor
Name:
BDBM50324678
Synonyms:
CHEMBL1222314 | thiophene-2-carboxylic acid
Type:
Small organic molecule
Emp. Form.:
C5H4O2S
Mol. Mass.:
128.149
SMILES:
OC(=O)c1cccs1
Structure:
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