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Target
Lysophosphatidylserine lipase ABHD12
Ligand
BDBM50470421
Substrate
n/a
Meas. Tech.
ChEMBL_1802961 (CHEMBL4275253)
IC50
>10000±n/a nM
Citation
 Bononi, G; Granchi, C; Lapillo, M; Giannotti, M; Nieri, D; Fortunato, S; Boustani, ME; Caligiuri, I; Poli, G; Carlson, KE; Kim, SH; Macchia, M; Martinelli, A; Rizzolio, F; Chicca, A; Katzenellenbogen, JA; Minutolo, F; Tuccinardi, T Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors. Eur J Med Chem 157:817-836 (2018) [PubMed]  Article 
Target
Name:
Lysophosphatidylserine lipase ABHD12
Synonyms:
ABD12_HUMAN | ABHD12 | C20orf22 | Monoacylglycerol lipase ABHD12
Type:
PROTEIN
Mol. Mass.:
45111.32
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1514755
Residue:
398
Sequence:
MRKRTEPVALEHERCAAAGSSSSGSAAAALDADCRLKQNLRLTGPAAAEPRCAADAGMKRALGRRKGVWLRLRKILFCVLGLYIAIPFLIKLCPGIQAKLIFLNFVRVPYFIDLKKPQDQGLNHTCNYYLQPEEDVTIGVWHTVPAVWWKNAQGKDQMWYEDALASSHPIILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTPSERGMTYDALHVFDWIKARSGDNPVYIWGHSLGTGVATNLVRRLCERETPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWFFLDPITSSGIKFANDENVKHISCPLLILHAEDDPVVPFQLGRKLYSIAAPARSFRDFKVQFVPFHSDLGYRHKYIYKSPELPRILREFLGKSEPEHQH
  
Inhibitor
Name:
BDBM50470421
Synonyms:
CHEMBL4293423
Type:
Small organic molecule
Emp. Form.:
C26H36FNO3
Mol. Mass.:
429.5673
SMILES:
CCCCCCCCCCCCC\C(=N/O)c1cc(ccc1O)-c1ccc(O)c(F)c1
Structure:
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