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Target
Retinoic acid receptor alpha
Ligand
BDBM50471287
Substrate
n/a
Meas. Tech.
ChEMBL_197405 (CHEMBL799795)
Kd
27±n/a nM
Citation
 Teng, M; Duong, TT; Johnson, AT; Klein, ES; Wang, L; Khalifa, B; Chandraratna, RA Identification of highly potent retinoic acid receptor alpha-selective antagonists. J Med Chem 40:2445-51 (1997) [PubMed]  Article 
Target
Name:
Retinoic acid receptor alpha
Synonyms:
NR1B1 | Nuclear receptor subfamily 1 group B member 1 | RAR-alpha | RARA | RARA_HUMAN | Retinoic acid receptor alpha | Retinoic acid receptor alpha/Retinoid X receptor alpha | Retinoid X receptor gamma/retinoic acid receptor alpha | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50778.87
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1466191
Residue:
462
Sequence:
MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPATIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP
  
Inhibitor
Name:
BDBM50471287
Synonyms:
CHEMBL81176
Type:
Small organic molecule
Emp. Form.:
C27H25NO3
Mol. Mass.:
411.4923
SMILES:
Cc1ccc(cc1)C1=CCC(C)(C)c2ccc(cc12)C(=O)Nc1ccc(cc1)C(O)=O |t:8|
Structure:
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