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Target
5-hydroxytryptamine receptor 1B
Ligand
BDBM50473517
Substrate
n/a
Meas. Tech.
ChEMBL_1371 (CHEMBL616444)
IC50
1349±n/a nM
Citation
 Jandu, KS; Barrett, V; Brockwell, M; Cambridge, D; Farrant, DR; Foster, C; Giles, H; Glen, RC; Hill, AP; Hobbs, H; Honey, A; Martin, GR; Salmon, J; Smith, D; Woollard, P; Selwood, DL Discovery of 4-[3-(trans-3-dimethylaminocyclobutyl)-1H-indol-5-ylmethyl]-(4S)-oxazolidin-2-one (4991W93), a 5HT(1B/1D) receptor partial agonist and a potent inhibitor of electrically induced plasma extravasation. J Med Chem 44:681-93 (2001) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1B
Synonyms:
5-HT-1B | 5-HT-1D-beta | 5-HT1B | 5-hydroxytryptamine receptor 1B (5-HT1B) | 5HT1B_HUMAN | HTR1B | HTR1DB | S12 | Serotonin (5-HT) receptor | Serotonin 1D beta receptor | Serotonin Receptor 1B
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
43579.17
Organism:
Homo sapiens (Human)
Description:
Receptor binding assays were performed using human clone stably expressed in CHO cells
Residue:
390
Sequence:
MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTS
  
Inhibitor
Name:
BDBM50473517
Synonyms:
CHEMBL348811
Type:
Small organic molecule
Emp. Form.:
C16H21N3O
Mol. Mass.:
271.3574
SMILES:
CN(C)[C@H]1C[C@@H](C1)c1c[nH]c2ccc(CC(N)=O)cc12 |wU:5.7,wD:3.2,(12.37,-11.41,;10.85,-11.09,;9.83,-12.25,;10.37,-9.64,;11.06,-8.26,;9.68,-7.57,;8.99,-8.94,;9.2,-6.11,;10.1,-4.85,;9.19,-3.62,;7.72,-4.11,;6.39,-3.34,;5.06,-4.11,;5.06,-5.65,;3.72,-6.42,;3.72,-7.94,;2.39,-8.73,;5.06,-8.73,;6.39,-6.42,;7.73,-5.65,)|
Structure:
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