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Target
UDP-N-acetylmuramate--L-alanine ligase
Ligand
BDBM50475581
Substrate
n/a
Meas. Tech.
ChEMBL_328936 (CHEMBL859886)
IC50
38600±n/a nM
Citation
 Antane, S; Caufield, CE; Hu, W; Keeney, D; Labthavikul, P; Morris, K; Naughton, SM; Petersen, PJ; Rasmussen, BA; Singh, G; Yang, Y Pulvinones as bacterial cell wall biosynthesis inhibitors. Bioorg Med Chem Lett 16:176-80 (2006) [PubMed]  Article 
Target
Name:
UDP-N-acetylmuramate--L-alanine ligase
Synonyms:
MURC_ECOLI | MurC (E. coli) | UDP-N-acetylmuramate--L-alanine ligase | murC
Type:
Protein
Mol. Mass.:
53617.78
Organism:
Escherichia coli
Description:
P17952
Residue:
491
Sequence:
MNTQQLAKLRSIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQLMNLGATIYFNHRPENVRDASVVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRHGIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAGVHARLGHGRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYQGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELLPRVGRQTTTYGFSEDADVRVEDYQQIGPQGHFTLLRQDKEPMRVTLNAPGRHNALNAAAAVAVATEEGIDDEAILRALESFQGTGRRFDFLGEFPLEPVNGKSGTAMLVDDYGHHPTEVDATIKAARAGWPDKNLVMLFQPHRFTRTRDLYDDFANVLTQVDTLLMLEVYPAGEAPIPGADSRSLCRTIRGRGKIDPILVPDPARVAEMLAPVLTGNDLILVQGAGNIGKIARSLAEIKLKPQTPEEEQHD
  
Inhibitor
Name:
BDBM50475581
Synonyms:
CHEMBL382548
Type:
Small organic molecule
Emp. Form.:
C19H13F3O4
Mol. Mass.:
362.2993
SMILES:
COc1ccc(cc1)C1=C(O)O\C(=C/c2cccc(c2)C(F)(F)F)C1=O |c:9|
Structure:
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