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Target
UDP-N-acetylmuramoylalanine--D-glutamate ligase
Ligand
BDBM50475597
Substrate
n/a
Meas. Tech.
ChEMBL_328940 (CHEMBL859890)
IC50
>53200±n/a nM
Citation
 Antane, S; Caufield, CE; Hu, W; Keeney, D; Labthavikul, P; Morris, K; Naughton, SM; Petersen, PJ; Rasmussen, BA; Singh, G; Yang, Y Pulvinones as bacterial cell wall biosynthesis inhibitors. Bioorg Med Chem Lett 16:176-80 (2006) [PubMed]  Article 
Target
Name:
UDP-N-acetylmuramoylalanine--D-glutamate ligase
Synonyms:
MURD_STAAU | MurD (S. aureus) | murD
Type:
Protein
Mol. Mass.:
49837.61
Organism:
Staphylococcus aureus (Firmicutes)
Description:
S. aureus MurD
Residue:
449
Sequence:
MLNYTGLENKNVLVVGLAKSGYEAAKLLSKLGANVTVNDGKDLSQDAHAKDLESMGISVVSGSHPLTLLDNNPIIVKNPGIPYTVSIIDEAVKRGLKILTEVELSYLISEAPIIAVTGTNGKTTVTSLIGDMFKKSRLTGRLSGNIGYVASKVAQEVKPTDYLVTELSSFQLLGIEKYKPHIAIITNIYSAHLDYHENLENYQNAKKQIYKNQTEEDYLICNYHQRQVIESEELKAKTLYFSTQQEVDGIYIKDGFIVYKGVRIINTEDLVLPGEHNLENILAAVLACILAGVPIKAIIDSLTTFSGIEHRLQYVGTNRTNKYYNDSKATNTLATQFALNSFNQPIIWLCGGLDRGNEFDELIPYMENVRAMVVFGQTKAKFAKLGNSQGKSVIEANNVEDAVDKVQDIIEPNDVVLLSPACASWDQYSTFEERGEKFIERFRAHLPSY
  
Inhibitor
Name:
BDBM50475597
Synonyms:
CHEMBL380752
Type:
Small organic molecule
Emp. Form.:
C22H16ClF4NO4
Mol. Mass.:
469.813
SMILES:
OC1=C(C(=O)O\C1=C/c1cc(ccc1Cl)C(F)(F)F)c1ccc(N2CCOCC2)c(F)c1 |t:1|
Structure:
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