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Target
Reverse transcriptase
Ligand
BDBM2325
Substrate
n/a
Meas. Tech.
ChEMBL_450285 (CHEMBL900566)
Ki
5.0±n/a nM
Citation
 Mai, A; Artico, M; Rotili, D; Tarantino, D; Clotet-Codina, I; Armand-Ugón, M; Ragno, R; Simeoni, S; Sbardella, G; Nawrozkij, MB; Samuele, A; Maga, G; Esté, JA Synthesis and biological properties of novel 2-aminopyrimidin-4(3H)-ones highly potent against HIV-1 mutant strains. J Med Chem 50:5412-24 (2007) [PubMed]  Article 
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM2325
Synonyms:
2-(cyclopentylsulfanyl)-6-[1-(2,6-difluorophenyl)ethyl]-5-methyl-3,4-dihydropyrimidin-4-one | S-DABO | thio-DABO 3w
Type:
Small organic molecule
Emp. Form.:
C18H20F2N2OS
Mol. Mass.:
350.426
SMILES:
CC(c1nc(SC2CCCC2)[nH]c(=O)c1C)c1c(F)cccc1F
Structure:
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