Reaction Details
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Cholesterol side-chain cleavage enzyme, mitochondrial
Ligand
BDBM50478886
Substrate
n/a
Meas. Tech.
ChEMBL_525780 (CHEMBL969144)
IC50
2000±n/a nM
Citation
Socha, AM; Garcia, D; Sheffer, R; Rowley, DC Antibiotic bisanthraquinones produced by a streptomycete isolated from a cyanobacterium associated with Ecteinascidia turbinata. J Nat Prod 69:1070-3 (2006) [PubMed] Article More Info.:
Target
Name:
Cholesterol side-chain cleavage enzyme, mitochondrial
Synonyms:
CP11A_RAT | Cyp11a | Cyp11a-1 | Cyp11a1 | Cytochrome P450 11A1
Type:
PROTEIN
Mol. Mass.:
60603.33
Organism:
Rattus norvegicus
Description:
ChEMBL_50353
Residue:
526
Sequence:
MLAKGLCLRSVLVKSCQPFLSPVWQGPGLATGNGAGISSTNSPRSFNEIPSPGDNGWINLYHFLRENGTHRIHYHHMQNFQKYGPIYREKLGNMESVYILDPKDAATLFSCEGPNPERYLVPPWVAYHQYYQRPIGVLFKSSDAWRKDRIVLNQEVMAPDSIKNFVPLLEGVAQDFIKVLHRRIKQQNSGKFSGDISDDLFRFAFESITSVVFGERLGMLEEIVDPESQRFIDAVYQMFHTSVPMLNMPPDLFRLFRTKTWKDHAAAWDVIFSKADEYTQNFYWDLRQKRDFSKYPGVLYSLLGGNKLPFKNIQANITEMLAGGVDTTSMTLQWNLYEMAHNLKVQEMLRAEVLAARRQAQGDMAKMVQLVPLLKASIKETLRLHPISVTLQRYIVNDLVLRNYKIPAKTLVQVASYAMGRESSFFPNPNKFDPTRWLEKSQNTTHFRYLGFGWGVRQCLGRRIAELEMTIFLINVLENFRIEVQSIRDVGTKFNLILMPEKPIFFNFQPLKQDLGSTMPRKGDTV
Inhibitor
Name:
BDBM50478886
Synonyms:
CHEMBL501116
Type:
Small organic molecule
Emp. Form.:
C32H24O9
Mol. Mass.:
552.5276
SMILES:
[H][C@]12[C@H](C)O[C@]34Oc5c(ccc6C(=O)c7cc(C)cc(O)c7C(=O)c56)C13C(=C(O)C[C@@]2(C)O)C(=O)c1c(O)cccc41 |r,t:31|
Structure:
