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Found 96 with Last Name = 'rowley' and Initial = 'dc'
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054502(CHEMBL140494 | N-((S)-3-Carbamimidoyl-2-hydroxy-cy...)
Affinity DataKi:  1.01nMAssay Description:compound was tested in vitro for inhibition of serine protease thrombin(FIIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054498((R)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrro...)
Affinity DataIC50:  0.700nMAssay Description:In vitro for inhibition of serine protease thrombin(FIIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054493(CHEMBL343805 | N-((S)-3-Carbamimidoyl-2-hydroxy-cy...)
Affinity DataIC50:  0.710nMAssay Description:In vitro for inhibition of serine protease thrombin(FIIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM50290996(3-tert-Butoxycarbonylamino-4-[2-(4-guanidino-1-phe...)
Affinity DataIC50:  0.760nMAssay Description:Compound was evaluated for its 50% inhibitory concentration against cow protease enzyme trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054492((S)-4-[(R)-2-((S)-3-Carbamimidoyl-2-hydroxy-cycloh...)
Affinity DataIC50:  1.10nMAssay Description:In vitro for inhibition of serine protease thrombin(FIIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054494(2-({(S)-1-[((S)-3-Carbamimidoyl-2-hydroxy-cyclohex...)
Affinity DataIC50:  1.12nMAssay Description:In vitro for inhibition of serine protease thrombin(FIIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054492((S)-4-[(R)-2-((S)-3-Carbamimidoyl-2-hydroxy-cycloh...)
Affinity DataIC50:  1.36nMAssay Description:In vitro for inhibition of serine protease Trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054498((R)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrro...)
Affinity DataIC50:  1.52nMAssay Description:In vitro for inhibition of serine protease Trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50290996(3-tert-Butoxycarbonylamino-4-[2-(4-guanidino-1-phe...)
Affinity DataIC50:  2.30nMAssay Description:Compound was evaluated for its 50 percent inhibitory concentration against human thrombin factor (FIIa)More data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054502(CHEMBL140494 | N-((S)-3-Carbamimidoyl-2-hydroxy-cy...)
Affinity DataIC50:  6.20nMAssay Description:In vitro for inhibition of serine protease thrombin(FIIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054504(2-((S)-3-Benzenesulfonylamino-2-oxo-azepan-1-yl)-N...)
Affinity DataIC50:  14.2nMAssay Description:In vitro for inhibition of serine protease thrombin(FIIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054504(2-((S)-3-Benzenesulfonylamino-2-oxo-azepan-1-yl)-N...)
Affinity DataIC50:  16.6nMAssay Description:In vitro for inhibition of serine protease Trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054493(CHEMBL343805 | N-((S)-3-Carbamimidoyl-2-hydroxy-cy...)
Affinity DataIC50:  20.6nMAssay Description:In vitro for inhibition of Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054493(CHEMBL343805 | N-((S)-3-Carbamimidoyl-2-hydroxy-cy...)
Affinity DataIC50:  74.5nMAssay Description:In vitro for inhibition of serine protease Trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM50290993(2-(N'-Acetyl-N-benzyl-hydrazinocarbonyl)-cyclohexa...)
Affinity DataIC50:  108nMAssay Description:Compound was evaluated for its 50% inhibitory concentration against cow protease enzyme trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054503(CHEMBL263924 | N-((1S,2R)-3-Carbamimidoyl-2-hydrox...)
Affinity DataIC50:  111nMAssay Description:In vitro for inhibition of serine protease thrombin(FIIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054505(CHEMBL421760 | N-(3-Carbamimidoyl-2-hydroxy-cycloh...)
Affinity DataIC50:  125nMAssay Description:compound was tested in vitro for inhibition of serine protease thrombin(FIIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054494(2-({(S)-1-[((S)-3-Carbamimidoyl-2-hydroxy-cyclohex...)
Affinity DataIC50:  137nMAssay Description:In vitro for inhibition of serine protease Trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054495(CHEMBL422470 | Lactum Sulfonamide analogue)
Affinity DataIC50:  147nMAssay Description:In vitro for inhibition of serine protease Trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM50289433((S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrro...)
Affinity DataIC50:  156nMAssay Description:Compound was evaluated for its 50% inhibitory concentration against cow protease enzyme trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054489(CHEMBL139656 | N-((S)-3-Carbamimidoyl-2-hydroxy-cy...)
Affinity DataIC50:  157nMAssay Description:In vitro for inhibition of serine protease thrombin(FIIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054491(2-((S)-3-Benzenesulfonylamino-2-oxo-piperidin-1-yl...)
Affinity DataIC50:  159nMAssay Description:In vitro for inhibition of serine protease thrombin(FIIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054495(CHEMBL422470 | Lactum Sulfonamide analogue)
Affinity DataIC50:  235nMAssay Description:In vitro for inhibition of serine protease thrombin(FIIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM50291000(CHEMBL110631 | {N'-tert-Butoxycarbonyl-N-[2-(1-for...)
Affinity DataIC50:  250nMAssay Description:Compound was evaluated for its 50% inhibitory concentration against cow protease enzyme trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine protease 1(Bos taurus (bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM50290999(CHEMBL322034 | {N'-tert-Butoxycarbonyl-N-[2-(4-gua...)
Affinity DataIC50:  250nMAssay Description:Compound was evaluated for its 50% inhibitory concentration against cow protease enzyme trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine protease 1(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50290994(CHEMBL432019 | N'-Benzyl-N'-[2-(4-guanidino-1-phen...)
Affinity DataIC50:  250nMAssay Description:Compound was evaluated for its 50% inhibitory concentration against human protease enzyme trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50289433((S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrro...)
Affinity DataIC50:  284nMAssay Description:Compound was evaluated for its 50 percent inhibitory concentration against human thrombin factor (FIIa)More data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054499(CHEMBL334454 | N-((S)-3-Carbamimidoyl-2-hydroxy-cy...)
Affinity DataIC50:  286nMAssay Description:In vitro for inhibition of serine protease thrombin(FIIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054492((S)-4-[(R)-2-((S)-3-Carbamimidoyl-2-hydroxy-cycloh...)
Affinity DataIC50:  290nMAssay Description:In vitro for inhibition of Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnionic trypsin(Bos taurus)
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054499(CHEMBL334454 | N-((S)-3-Carbamimidoyl-2-hydroxy-cy...)
Affinity DataIC50:  293nMAssay Description:compound was tested in vitro for inhibition of serine protease Trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054490(CHEMBL138243 | N-((S)-3-Carbamimidoyl-2-hydroxy-cy...)
Affinity DataIC50:  420nMAssay Description:In vitro for inhibition of serine protease thrombin(FIIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054489(CHEMBL139656 | N-((S)-3-Carbamimidoyl-2-hydroxy-cy...)
Affinity DataIC50:  467nMAssay Description:In vitro for inhibition of serine protease Trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054494(2-({(S)-1-[((S)-3-Carbamimidoyl-2-hydroxy-cyclohex...)
Affinity DataIC50:  471nMAssay Description:In vitro for inhibition of Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054504(2-((S)-3-Benzenesulfonylamino-2-oxo-azepan-1-yl)-N...)
Affinity DataIC50:  479nMAssay Description:In vitro for inhibition of Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnionic trypsin(Bos taurus)
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054505(CHEMBL421760 | N-(3-Carbamimidoyl-2-hydroxy-cycloh...)
Affinity DataIC50:  538nMAssay Description:compound was tested in vitro for inhibition of serine protease Trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM50290998(CHEMBL109044 | {N'-Acetyl-N-[2-(1-formyl-4-guanidi...)
Affinity DataIC50:  590nMAssay Description:Compound was evaluated for its 50% inhibitory concentration against cow protease enzyme trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCoagulation factor X(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50290996(3-tert-Butoxycarbonylamino-4-[2-(4-guanidino-1-phe...)
Affinity DataIC50:  698nMAssay Description:Compound was evaluated for its 50% inhibitory concentration against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCoagulation factor VII(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290996(3-tert-Butoxycarbonylamino-4-[2-(4-guanidino-1-phe...)
Affinity DataIC50:  706nMAssay Description:Compound was evaluated for its 50 percent inhibitory concentration against human Coagulation factor VIIMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054501(2-[(S)-3-(Butane-1-sulfonylamino)-2-oxo-piperidin-...)
Affinity DataIC50:  709nMAssay Description:In vitro for inhibition of serine protease thrombin(FIIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054491(2-((S)-3-Benzenesulfonylamino-2-oxo-piperidin-1-yl...)
Affinity DataIC50:  770nMAssay Description:In vitro for inhibition of serine protease Trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054502(CHEMBL140494 | N-((S)-3-Carbamimidoyl-2-hydroxy-cy...)
Affinity DataIC50:  791nMAssay Description:In vitro for inhibition of serine protease Trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50290994(CHEMBL432019 | N'-Benzyl-N'-[2-(4-guanidino-1-phen...)
Affinity DataIC50:  880nMAssay Description:Compound was evaluated for its 50 percent inhibitory concentration against human thrombin factor (FIIa)More data for this Ligand-Target Pair
In DepthDetails Article
TargetAnionic trypsin(Bos taurus)
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054503(CHEMBL263924 | N-((1S,2R)-3-Carbamimidoyl-2-hydrox...)
Affinity DataIC50:  1.02E+3nMAssay Description:compound was tested in vitro for inhibition of serine protease Trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054491(2-((S)-3-Benzenesulfonylamino-2-oxo-piperidin-1-yl...)
Affinity DataIC50:  1.10E+3nMAssay Description:In vitro for inhibition of Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM50291003(CHEMBL326462 | {N'-tert-Butoxycarbonyl-N-[2-(4-gua...)
Affinity DataIC50:  1.31E+3nMAssay Description:Compound was evaluated for its 50% inhibitory concentration against cow protease enzyme trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054500(CHEMBL140646 | {(S)-1-[((S)-3-Carbamimidoyl-2-hydr...)
Affinity DataIC50:  1.46E+3nMAssay Description:In vitro for inhibition of serine protease thrombin(FIIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholesterol side-chain cleavage enzyme, mitochondrial(Rattus norvegicus)
University Of Rhode Island

Curated by ChEMBL
LigandPNGBDBM50237605(Achromycin | Achromycin V | CHEBI:27902 | Cyclopar...)
Affinity DataIC50:  1.57E+3nMAssay Description:Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 51299 after 18 hrs by broth dilution assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054495(CHEMBL422470 | Lactum Sulfonamide analogue)
Affinity DataIC50:  1.95E+3nMAssay Description:In vitro for inhibition of Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholesterol side-chain cleavage enzyme, mitochondrial(Rattus norvegicus)
University Of Rhode Island

Curated by ChEMBL
LigandPNGBDBM50478886(CHEMBL501116)
Affinity DataIC50:  2.00E+3nMAssay Description:Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 51299 after 18 hrs by broth dilution assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50054489(CHEMBL139656 | N-((S)-3-Carbamimidoyl-2-hydroxy-cy...)
Affinity DataIC50:  2.50E+3nMAssay Description:In vitro for inhibition of Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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