Reaction Details Report a problem with these data
Target
Tubulin beta chain
Ligand
BDBM50479547
Substrate
n/a
Meas. Tech.
ChEMBL_495611 (CHEMBL1000303)
IC50
520±n/a nM
Citation
 Prinz, H; Schmidt, P; Böhm, KJ; Baasner, S; Müller, K; Unger, E; Gerlach, M; Günther, EG 10-(2-oxo-2-phenylethylidene)-10H-anthracen-9-ones as highly active antimicrotubule agents: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem 52:1284-94 (2009) [PubMed]  Article 
Target
Name:
Tubulin beta chain
Synonyms:
Beta-tubulin | TBB_PIG | Tubulin beta chain
Type:
PROTEIN
Mol. Mass.:
49840.26
Organism:
Sus scrofa
Description:
ChEMBL_105107
Residue:
445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEGEEDEA
  
Inhibitor
Name:
BDBM50479547
Synonyms:
CHEMBL455138
Type:
Small organic molecule
Emp. Form.:
C23H16O3
Mol. Mass.:
340.3713
SMILES:
[#6]-[#8]-c1ccc(cc1)-[#6](=O)\[#6]=[#6]-1\c2ccccc2-[#6](=O)-c2ccccc-12
Structure:
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