Reaction Details Report a problem with these data
Target
Potassium channel subfamily K member 10
Ligand
BDBM50482294
Substrate
n/a
Meas. Tech.
ChEMBL_640600 (CHEMBL1175513)
IC50
100000±n/a nM
Citation
 Kim, EJ; Ryu, HW; Curtis-Long, MJ; Han, J; Kim, JY; Cho, JK; Kang, D; Park, KH Chemoselective regulation of TREK2 channel: activation by sulfonate chalcones and inhibition by sulfonamide chalcones. Bioorg Med Chem Lett 20:4237-9 (2010) [PubMed]  Article 
Target
Name:
Potassium channel subfamily K member 10
Synonyms:
KCNKA_RAT | Kcnk10 | Outward rectifying potassium channel protein TREK-2 | Potassium channel subfamily K member 10 | TREK-2 K(+) channel subunit | Trek2
Type:
PROTEIN
Mol. Mass.:
59814.68
Organism:
Rattus norvegicus
Description:
ChEMBL_109237
Residue:
538
Sequence:
MKFPIETPRKQVNWDPKVAVPAAAPPVCQPKSATNGHHPVPRLSISSRATVVARMEGASQGGLQTVMKWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHICVSPQELETLIQHALDADNAGVSPVGNSSNSSSHWDLGSAFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARVEKVFRKKQVSQTKIRVISTILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTLTTVGFGDFVAGGNAGINYREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSKKTKEEVGEIKAHAAEWKANVTAEFRETRRRLSVEIHDKLQRAATIRSMERRRLGLDQRAHSLDMLSPEKRSVFAALDTGRFKASSQESINNRPNNLRLKGPEQLNKHGQGASEDNIINKFGSTSKLTKRKNKDLKKTLPEDVQKIYKTFRNYSLDEEKKEDETEKMCNSDNSSTAMLTECIQQQAEMENGMVPMDTKDQGLENNSLLEDRN
  
Inhibitor
Name:
BDBM50482294
Synonyms:
CHEMBL1170811
Type:
Small organic molecule
Emp. Form.:
C23H21NO4S
Mol. Mass.:
407.482
SMILES:
COc1ccc(\C=C\C(=O)c2ccc(NS(=O)(=O)c3ccc(C)cc3)cc2)cc1
Structure:
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