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Target
Tubulin beta chain
Ligand
BDBM50482374
Substrate
n/a
Meas. Tech.
ChEMBL_644542 (CHEMBL1211419)
IC50
510±n/a nM
Citation
 Nickel, HC; Schmidt, P; Böhm, KJ; Baasner, S; Müller, K; Gerlach, M; Unger, E; Günther, EG; Prinz, H Synthesis, antiproliferative activity and inhibition of tubulin polymerization by 1,5- and 1,8-disubstituted 10H-anthracen-9-ones bearing a 10-benzylidene or 10-(2-oxo-2-phenylethylidene) moiety. Eur J Med Chem 45:3420-38 (2010) [PubMed]  Article 
Target
Name:
Tubulin beta chain
Synonyms:
Beta-tubulin | TBB_PIG | Tubulin beta chain
Type:
PROTEIN
Mol. Mass.:
49840.26
Organism:
Sus scrofa
Description:
ChEMBL_105107
Residue:
445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEGEEDEA
  
Inhibitor
Name:
BDBM50482374
Synonyms:
CHEMBL1210416
Type:
Small organic molecule
Emp. Form.:
C22H11BrCl2O2
Mol. Mass.:
458.132
SMILES:
Clc1cccc2\C(=C/C(=O)c3ccc(Br)cc3)c3c(Cl)cccc3C(=O)c12
Structure:
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