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Target
Eukaryotic initiation factor 4A-I
Ligand
BDBM50235738
Substrate
n/a
Meas. Tech.
ChEMBL_653215 (CHEMBL1226418)
IC50
400±n/a nM
Citation
 Bordeleau, ME; Mori, A; Oberer, M; Lindqvist, L; Chard, LS; Higa, T; Belsham, GJ; Wagner, G; Tanaka, J; Pelletier, J Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A. Nat Chem Biol 2:213-20 (2006) [PubMed]  Article 
Target
Name:
Eukaryotic initiation factor 4A-I
Synonyms:
ATP-dependent RNA helicase eIF4A-1 | DDX2A | EIF4A | EIF4A1 | IF4A1_HUMAN | eIF-4A-I | eIF4A-I
Type:
PROTEIN
Mol. Mass.:
46146.87
Organism:
Homo sapiens (Human)
Description:
ChEMBL_864983
Residue:
406
Sequence:
MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI
  
Inhibitor
Name:
BDBM50235738
Synonyms:
Hippuristanol
Type:
Small organic molecule
Emp. Form.:
C28H46O5
Mol. Mass.:
462.6618
SMILES:
[H][C@]12C[C@@]3([H])[C@]4([H])CC[C@@]5([H])C[C@H](O)CC[C@]5(C)[C@@]4([H])[C@@H](O)C[C@]3(C)[C@@]1([H])[C@@](C)(O)[C@]1(C[C@H](C)C(C)(C)O1)O2 |r|
Structure:
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