Reaction Details Report a problem with these data
Target
Tubulin beta chain
Ligand
BDBM50483993
Substrate
n/a
Meas. Tech.
ChEMBL_755967 (CHEMBL1803857)
IC50
520±n/a nM
Citation
 Prinz, H; Chamasmani, B; Vogel, K; Böhm, KJ; Aicher, B; Gerlach, M; Günther, EG; Amon, P; Ivanov, I; Müller, K N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem 54:4247-63 (2011) [PubMed]  Article 
Target
Name:
Tubulin beta chain
Synonyms:
Beta-tubulin | TBB_PIG | Tubulin beta chain
Type:
PROTEIN
Mol. Mass.:
49840.26
Organism:
Sus scrofa
Description:
ChEMBL_105107
Residue:
445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEGEEDEA
  
Inhibitor
Name:
BDBM50483993
Synonyms:
CHEMBL1802017
Type:
Small organic molecule
Emp. Form.:
C21H14N2O4
Mol. Mass.:
358.3469
SMILES:
COc1ccc(cc1O)C(=O)N1c2ccccc2Oc2cc(ccc12)C#N
Structure:
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