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Target
Presenilin-1
Ligand
BDBM50484465
Substrate
n/a
Meas. Tech.
ChEMBL_787715 (CHEMBL1918257)
IC50
8.0±n/a nM
Citation
 Stepan, AF; Karki, K; McDonald, WS; Dorff, PH; Dutra, JK; Dirico, KJ; Won, A; Subramanyam, C; Efremov, IV; O'Donnell, CJ; Nolan, CE; Becker, SL; Pustilnik, LR; Sneed, B; Sun, H; Lu, Y; Robshaw, AE; Riddell, D; O'Sullivan, TJ; Sibley, E; Capetta, S; Atchison, K; Hallgren, AJ; Miller, E; Wood, A; Obach, RS Metabolism-directed design of oxetane-containing arylsulfonamide derivatives as ?-secretase inhibitors. J Med Chem 54:7772-83 (2011) [PubMed]  Article 
Target
Name:
Presenilin-1
Synonyms:
3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182
Type:
n/a
Mol. Mass.:
52657.13
Organism:
Homo sapiens (Human)
Description:
P49768
Residue:
467
Sequence:
MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
  
Inhibitor
Name:
BDBM50484465
Synonyms:
CHEMBL1916331
Type:
Small organic molecule
Emp. Form.:
C15H18ClF3N2O4S
Mol. Mass.:
414.828
SMILES:
NC(=O)[C@@H](CCC(F)(F)F)N(C[C@@H]1CCO1)S(=O)(=O)c1ccc(Cl)cc1 |r|
Structure:
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