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Target
Solute carrier organic anion transporter family member 4C1
Ligand
BDBM46356
Substrate
n/a
Meas. Tech.
ChEMBL_836924 (CHEMBL2075764)
IC50
120±n/a nM
Citation
 Mikkaichi, T; Suzuki, T; Onogawa, T; Tanemoto, M; Mizutamari, H; Okada, M; Chaki, T; Masuda, S; Tokui, T; Eto, N; Abe, M; Satoh, F; Unno, M; Hishinuma, T; Inui, K; Ito, S; Goto, J; Abe, T Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. Proc Natl Acad Sci U S A 101:3569-74 (2004) [PubMed]  Article 
Target
Name:
Solute carrier organic anion transporter family member 4C1
Synonyms:
OATP-H | OATP-M1 | OATP4C1 | OATPX | Organic anion transporter M1 | SLC21A20 | SLCO4C1 | SO4C1_HUMAN | Solute carrier family 21 member 20 | Solute carrier organic anion transporter family member 4C1
Type:
PROTEIN
Mol. Mass.:
78955.06
Organism:
Homo sapiens
Description:
ChEMBL_104631
Residue:
724
Sequence:
MKSAKGIENLAFVPSSPDILRRLSASPSQIEVSALSSDPQRENSQPQELQKPQEPQKSPEPSLPSAPPNVSEEKLRSLSLSEFEEGSYGWRNFHPQCLQRCNTPGGFLLHYCLLAVTQGIVVNGLVNISISTVEKRYEMKSSLTGLISSSYDISFCLLSLFVSFFGERGHKPRWLAFAAFMIGLGALVFSLPQFFSGEYKLGSLFEDTCVTTRNSTSCTSSTSSLSNYLYVFILGQLLLGAGGTPLYTLGTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTIYIDVAMGESTDVTEDDPRWLGAWWIGFLLSWIFAWSLIIPFSCFPKHLPGTAEIQAGKTSQAHQSNSNADVKFGKSIKDFPAALKNLMKNAVFMCLVLSTSSEALITTGFATFLPKFIENQFGLTSSFAATLGGAVLIPGAALGQILGGFLVSKFRMTCKNTMKFALFTSGVALTLSFVFMYAKCENEPFAGVSESYNGTGELGNLIAPCNANCNCSRSYYYPVCGDGVQYFSPCFAGCSNPVAHRKPKVYYNCSCIERKTEITSTAETFGFEAKAGKCETHCAKLPIFLCIFFIVIIFTFMAGTPITVSILRCVNHRQRSLALGIQFMVLRLLGTIPGPIIFGFTIDSTCILWDINDCGIKGACWIYDNIKMAHMLVAISVTCKVITMFFNGFAIFLYKPPPSATDVSFHKENAVVTNVLAEQDLNKIVKEG
  
Inhibitor
Name:
BDBM46356
Synonyms:
DIGITOXIN | MLS000069787 | SMR000058529 | US10668094, Compound Digitoxin | cid_441207
Type:
Small organic molecule
Emp. Form.:
C41H64O13
Mol. Mass.:
764.9391
SMILES:
C[C@H]1O[C@H](C[C@H](O)[C@@H]1O)O[C@H]1[C@@H](O)C[C@H](O[C@H]2[C@@H](O)C[C@H](O[C@H]3CC[C@@]4(C)[C@H](CC[C@@H]5[C@@H]4CC[C@]4(C)[C@H](CC[C@]54O)C4=CC(=O)OC4)C3)O[C@@H]2C)O[C@@H]1C |t:45|
Structure:
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