Reaction Details Report a problem with these data
Target
Arachidonate 5-lipoxygenase-activating protein
Ligand
BDBM50029570
Substrate
n/a
Meas. Tech.
ChEMBL_4307 (CHEMBL618416)
IC50
32±n/a nM
Citation
 Hutchinson, JH; Charleson, S; Evans, JF; Falgueyret, JP; Hoogsteen, K; Jones, TR; Kargman, S; Macdonald, D; McFarlane, CS; Nicholson, DW Thiopyranol[2,3,4-c,d]indoles as inhibitors of 5-lipoxygenase, 5-lipoxygenase-activating protein, and leukotriene C4 synthase. J Med Chem 38:4538-47 (1995) [PubMed]  Article 
Target
Name:
Arachidonate 5-lipoxygenase-activating protein
Synonyms:
5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:
Enzyme
Mol. Mass.:
18159.90
Organism:
Homo sapiens (Human)
Description:
P20292
Residue:
161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
  
Inhibitor
Name:
BDBM50029570
Synonyms:
CHEMBL139891 | {2-[1-(4-Chloro-benzyl)-4-methyl-6-(quinolin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-ylmethoxy]-phenyl}-acetic acid
Type:
Small organic molecule
Emp. Form.:
C37H31ClN2O4S
Mol. Mass.:
635.171
SMILES:
CC1Cc2c(OCc3ccc4ccccc4n3)ccc3n(Cc4ccc(Cl)cc4)c(COc4ccccc4CC(O)=O)c(S1)c23
Structure:
Search PDB for entries with ligand similarity: