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Target
Reverse transcriptase/RNaseH
Ligand
BDBM50029672
Substrate
n/a
Meas. Tech.
ChEMBL_195839 (CHEMBL799138)
IC50
>4000±n/a nM
Citation
 Dollé, V; Fan, E; Nguyen, CH; Aubertin, AM; Kirn, A; Andreola, ML; Jamieson, G; Tarrago-Litvak, L; Bisagni, E A new series of pyridinone derivatives as potent non-nucleoside human immunodeficiency virus type 1 specific reverse transcriptase inhibitors. J Med Chem 38:4679-86 (1995) [PubMed]  Article 
Target
Name:
Reverse transcriptase/RNaseH
Synonyms:
HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH
Type:
PROTEIN
Mol. Mass.:
65229.15
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_1473730
Residue:
566
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKVLFLDGID
  
Inhibitor
Name:
BDBM50029672
Synonyms:
CHEMBL341880 | N-[4-(3,5-Dimethyl-phenylsulfanyl)-5-methyl-2-oxo-1,2-dihydro-pyridin-3-yl]-acetamide
Type:
Small organic molecule
Emp. Form.:
C16H18N2O2S
Mol. Mass.:
302.391
SMILES:
CC(=O)Nc1c(Sc2cc(C)cc(C)c2)c(C)c[nH]c1=O
Structure:
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