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Target
Gastrin/cholecystokinin type B receptor
Ligand
BDBM50037866
Substrate
n/a
Meas. Tech.
ChEMBL_47965 (CHEMBL653979)
IC50
1.07±n/a nM
Citation
 Lowe, JA; Hageman, DL; Drozda, SE; McLean, S; Bryce, DK; Crawford, RT; Zorn, S; Morrone, J; Bordner, J 5-Phenyl-3-ureidobenzazepin-2-ones as cholecystokinin-B receptor antagonists. J Med Chem 37:3789-811 (1994) [PubMed]  Article 
Target
Name:
Gastrin/cholecystokinin type B receptor
Synonyms:
CCK-2 receptor | CCK-B receptor | CCK-BR | CCKBR | CCKRB | Cholecystokinin A | Cholecystokinin receptor | Cholecystokinin-2 Receptor | GASR_HUMAN | Gastrin/cholecystokinin type B receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48445.79
Organism:
Homo sapiens (Human)
Description:
Stable expression of human CCK-2 receptors in HEK 293 cells.
Residue:
447
Sequence:
MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRALPDEDPPTPSIASLSRLSYTTISTLGPG
  
Inhibitor
Name:
BDBM50037866
Synonyms:
CHEMBL125253 | N-tert-Butyl-2-{(3R,5R)-3-[3-(3-chloro-phenyl)-ureido]-5-cyclohexyl-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl}-acetamide
Type:
Small organic molecule
Emp. Form.:
C29H37ClN4O3
Mol. Mass.:
525.082
SMILES:
CC(C)(C)NC(=O)CN1c2ccccc2[C@H](C[C@@H](NC(=O)Nc2cccc(Cl)c2)C1=O)C1CCCCC1
Structure:
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