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Target
Carbonic anhydrase 2
Ligand
BDBM150249
Substrate
n/a
Meas. Tech.
ChEMBL_1276466 (CHEMBL3088590)
Ki
5.5±n/a nM
Citation
 Rami, M; Dubois, L; Parvathaneni, NK; Alterio, V; van Kuijk, SJ; Monti, SM; Lambin, P; De Simone, G; Supuran, CT; Winum, JY Hypoxia-targeting carbonic anhydrase IX inhibitors by a new series of nitroimidazole-sulfonamides/sulfamides/sulfamates. J Med Chem 56:8512-20 (2013) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM150249
Synonyms:
US8980932, 6a (DH307)
Type:
Small organic molecule
Emp. Form.:
C13H16N6O4S2
Mol. Mass.:
384.434
SMILES:
Cc1ncc(n1CCNC(=S)Nc1ccc(cc1)S(N)(=O)=O)[N+]([O-])=O
Structure:
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