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Target
Serine/threonine-protein kinase pim-3
Ligand
BDBM50499280
Substrate
n/a
Meas. Tech.
ChEMBL_1537949 (CHEMBL3738382)
IC50
6.4±n/a nM
Citation
 Nakano, H; Hasegawa, T; Saito, N; Furukawa, K; Mukaida, N; Kojima, H; Okabe, T; Nagano, T Design and synthesis of an in vivo-efficacious PIM3 kinase inhibitor as a candidate anti-pancreatic cancer agent. Bioorg Med Chem Lett 25:5687-93 (2015) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Homo sapiens (Human)
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
  
Inhibitor
Name:
BDBM50499280
Synonyms:
CHEMBL3735412
Type:
Small organic molecule
Emp. Form.:
C23H25N5O4
Mol. Mass.:
435.4757
SMILES:
CC(N1CCNCC1)c1c2O\C(=C/c3n[nH]c4ncccc34)C(=O)c2ccc1OCCO
Structure:
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