Reaction Details Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM50500593
Substrate
n/a
Meas. Tech.
ChEMBL_1548270 (CHEMBL3755537)
IC50
>1000±n/a nM
Citation
 Carotenuto, A; Merlino, F; Cai, M; Brancaccio, D; Yousif, AM; Novellino, E; Hruby, VJ; Grieco, P Discovery of Novel Potent and Selective Agonists at the Melanocortin-3 Receptor. J Med Chem 58:9773-8 (2015) [PubMed]  Article 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM50500593
Synonyms:
CHEMBL4299454
Type:
Small organic molecule
Emp. Form.:
C60H79N15O10
Mol. Mass.:
1170.3638
SMILES:
[H][C@@]12CCCN1C(=O)[C@H](Cc1c[nH]c3ccccc13)NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c3ccccc13)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](Cc1ccccc1)NC2=O)C(N)=O)NC(=O)[C@@H](CCCC)NC(C)=O |r|
Structure:
Search PDB for entries with ligand similarity: