Reaction Details Report a problem with these data
Target
Carbonic anhydrase 12
Ligand
BDBM50500681
Substrate
n/a
Meas. Tech.
ChEMBL_1549339 (CHEMBL3755045)
Ki
61±n/a nM
Citation
 Villalba, ML; Palestro, P; Ceruso, M; Gonzalez Funes, JL; Talevi, A; Bruno Blanch, L; Supuran, CT; Gavernet, L Sulfamide derivatives with selective carbonic anhydrase VII inhibitory action. Bioorg Med Chem 24:894-901 (2016) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 12
Synonyms:
CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3
Type:
Enzyme
Mol. Mass.:
39456.00
Organism:
Homo sapiens (Human)
Description:
Catalytic domain of human cloned isozyme was used in the assay
Residue:
354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
  
Inhibitor
Name:
BDBM50500681
Synonyms:
CHEMBL3754723
Type:
Small organic molecule
Emp. Form.:
C14H24N2O4S
Mol. Mass.:
316.416
SMILES:
COC(=O)CCNS(=O)(=O)NC12CC3CC(CC(C3)C1)C2 |TLB:18:13:20:17.16.19,18:17:20:14.13.12,THB:12:13:16:20.11.19,12:11:14.13.18:16,10:11:14.13.18:16|
Structure:
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