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Target
Endothelin receptor type B
Ligand
BDBM50051012
Substrate
n/a
Meas. Tech.
ChEMBL_63851 (CHEMBL673235)
Ki
343±n/a nM
Citation
 Winn, M; von Geldern, TW; Opgenorth, TJ; Jae, HS; Tasker, AS; Boyd, SA; Kester, JA; Mantei, RA; Bal, R; Sorensen, BK; Wu-Wong, JR; Chiou, WJ; Dixon, DB; Novosad, EI; Hernandez, L; Marsh, KC 2,4-Diarylpyrrolidine-3-carboxylic acids--potent ETA selective endothelin receptor antagonists. 1. Discovery of A-127722. J Med Chem 39:1039-48 (1996) [PubMed]  Article 
Target
Name:
Endothelin receptor type B
Synonyms:
EDNRB | EDNRB_HUMAN | ENDOTHELIN B | ET-B | ETRB | Endothelin receptor ET-B | Endothelin receptor non-selective type | Endothelin receptor, ET-A/ET-B
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49664.00
Organism:
Homo sapiens (Human)
Description:
ENDOTHELIN B EDNRB HUMAN::P24530
Residue:
442
Sequence:
MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNASLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS
  
Inhibitor
Name:
BDBM50051012
Synonyms:
4-tert-Butyl-N-[6-(3-hydroxy-propyl)-5-(2-methoxy-benzyl)-[2,2']bipyrimidinyl-4-yl]-benzenesulfonamide | CHEMBL428661
Type:
Small organic molecule
Emp. Form.:
C29H33N5O4S
Mol. Mass.:
547.668
SMILES:
COc1ccccc1Cc1c(CCCO)nc(nc1NS(=O)(=O)c1ccc(cc1)C(C)(C)C)-c1ncccn1
Structure:
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