Reaction Details Report a problem with these data
Target
Histamine H3 receptor
Ligand
BDBM50051194
Substrate
n/a
Meas. Tech.
ChEMBL_86902 (CHEMBL698412)
Ki
50±n/a nM
Citation
Stark, H; Purand, K; Ligneau, X; Rouleau, A; Arrang, JM; Garbarg, M; Schwartz, JC; Schunack, W Novel carbamates as potent histamine H3 receptor antagonists with high in vitro and oral in vivo activity. J Med Chem 39:1157-63 (1996) [PubMed] Article
More Info.:
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
Inhibitor
Name:
BDBM50051194
Synonyms:
(3-{[3-(1H-Imidazol-4-yl)-propoxycarbonylamino]-methyl}-benzyl)-carbamic acid 3-(1H-imidazol-4-yl)-propyl ester | CHEMBL415989
Type:
Small organic molecule
Emp. Form.:
C22H28N6O4
Mol. Mass.:
440.4955
SMILES:
O=C(NCc1cccc(CNC(=O)OCCCc2cnc[nH]2)c1)OCCCc1cnc[nH]1