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Target
Histamine H3 receptor
Ligand
BDBM50051203
Substrate
n/a
Meas. Tech.
ChEMBL_86902 (CHEMBL698412)
Ki
14±n/a nM
Citation
 Stark, H; Purand, K; Ligneau, X; Rouleau, A; Arrang, JM; Garbarg, M; Schwartz, JC; Schunack, W Novel carbamates as potent histamine H3 receptor antagonists with high in vitro and oral in vivo activity. J Med Chem 39:1157-63 (1996) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50051203
Synonyms:
(4-Chloro-benzyl)-carbamic acid 3-(1H-imidazol-4-yl)-propyl ester | CHEMBL277149
Type:
Small organic molecule
Emp. Form.:
C14H16ClN3O2
Mol. Mass.:
293.749
SMILES:
Clc1ccc(CNC(=O)OCCCc2cnc[nH]2)cc1
Structure:
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