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Target
Histamine H3 receptor
Ligand
BDBM50051215
Substrate
n/a
Meas. Tech.
ChEMBL_83832 (CHEMBL690973)
Ki
19.95±n/a nM
Citation
 Stark, H; Purand, K; Ligneau, X; Rouleau, A; Arrang, JM; Garbarg, M; Schwartz, JC; Schunack, W Novel carbamates as potent histamine H3 receptor antagonists with high in vitro and oral in vivo activity. J Med Chem 39:1157-63 (1996) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50051215
Synonyms:
(3-Nitro-phenyl)-carbamic acid 3-(1H-imidazol-4-yl)-propyl ester | CHEMBL279617
Type:
Small organic molecule
Emp. Form.:
C13H14N4O4
Mol. Mass.:
290.2747
SMILES:
[O-][N+](=O)c1cccc(NC(=O)OCCCc2cnc[nH]2)c1
Structure:
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