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Target
Sterol O-acyltransferase 1
Ligand
BDBM50051880
Substrate
n/a
Meas. Tech.
ChEMBL_28661 (CHEMBL643995)
IC50
110±n/a nM
Citation
 Astles, PC; Ashton, MJ; Bridge, AW; Harris, NV; Hart, TW; Parrott, DP; Porter, B; Riddell, D; Smith, C; Williams, RJ Acyl-CoA:Cholesterol O-acyltransferase (ACAT) inhibitors. 2. 2-(1,3-Dioxan-2-yl)-4,5-diphenyl-1H-imidazoles as potent inhibitors of ACAT. J Med Chem 39:1423-32 (1996) [PubMed]  Article 
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACACT | ACACT1 | ACAT | ACAT1 | Acetyl-CoA acetyltransferase, mitochondrial | Acyl coenzyme A:cholesterol acyltransferase 1 | Acyl-CoA: cholesterol acyltransferase (ACAT) | Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) | Cholesterol acyltransferase 1 | SOAT | SOAT1 | SOAT1_HUMAN | STAT
Type:
Multi-pass membrane protein may form homo- or heterodimers.
Mol. Mass.:
64751.94
Organism:
Homo sapiens (Human)
Description:
P35610
Residue:
550
Sequence:
MVGEEKMSLRNRLSKSRENPEEDEDQRNPAKESLETPSNGRIDIKQLIAKKIKLTAEAEELKPFFMKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSVLEGEKNNHRAKDLRAPPEQGKIFIARRSLLDELLEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGKFPTVVWTWWIMFLSTFSVPYFLFQHWATGYSKSSHPLIRSLFHGFLFMIFQIGVLGFGPTYVVLAYTLPPASRFIIIFEQIRFVMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLSFFYPVLFVLFMFFGMAFNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYARQHCPLKNPTFLDYVRPRSWTCRYVF
  
Inhibitor
Name:
BDBM50051880
Synonyms:
1-{4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[1,3]dioxan-5-yl]-butyl}-4-phenyl-1H-pyrazole | CHEMBL33464
Type:
Small organic molecule
Emp. Form.:
C33H34N4O2
Mol. Mass.:
518.6487
SMILES:
CC1(CCCCn2cc(cn2)-c2ccccc2)COC(OC1)c1nc(c([nH]1)-c1ccccc1)-c1ccccc1 |(11.58,-14.76,;10.83,-13.43,;12.04,-12.47,;13.47,-12.98,;14.66,-12.02,;16.09,-12.56,;17.43,-11.77,;17.75,-10.27,;19.29,-10.11,;19.91,-11.51,;18.76,-12.54,;20.06,-8.78,;21.6,-8.78,;22.38,-7.44,;21.61,-6.11,;20.06,-6.11,;19.29,-7.44,;10.06,-14.78,;8.35,-14.17,;7.15,-14.59,;7.93,-13.23,;9.56,-13.85,;5.81,-13.8,;5.41,-12.31,;3.87,-12.24,;3.3,-13.69,;4.52,-14.66,;1.82,-14.08,;.73,-13,;-.76,-13.41,;-1.16,-14.9,;-.05,-15.98,;1.43,-15.58,;3.02,-10.95,;1.48,-11.04,;.64,-9.75,;1.33,-8.36,;2.88,-8.29,;3.72,-9.57,)|
Structure:
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