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Target
Sterol O-acyltransferase 1
Ligand
BDBM50051885
Substrate
n/a
Meas. Tech.
ChEMBL_28661 (CHEMBL643995)
IC50
220±n/a nM
Citation
 Astles, PC; Ashton, MJ; Bridge, AW; Harris, NV; Hart, TW; Parrott, DP; Porter, B; Riddell, D; Smith, C; Williams, RJ Acyl-CoA:Cholesterol O-acyltransferase (ACAT) inhibitors. 2. 2-(1,3-Dioxan-2-yl)-4,5-diphenyl-1H-imidazoles as potent inhibitors of ACAT. J Med Chem 39:1423-32 (1996) [PubMed]  Article 
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACACT | ACACT1 | ACAT | ACAT1 | Acetyl-CoA acetyltransferase, mitochondrial | Acyl coenzyme A:cholesterol acyltransferase 1 | Acyl-CoA: cholesterol acyltransferase (ACAT) | Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) | Cholesterol acyltransferase 1 | SOAT | SOAT1 | SOAT1_HUMAN | STAT
Type:
Multi-pass membrane protein may form homo- or heterodimers.
Mol. Mass.:
64751.94
Organism:
Homo sapiens (Human)
Description:
P35610
Residue:
550
Sequence:
MVGEEKMSLRNRLSKSRENPEEDEDQRNPAKESLETPSNGRIDIKQLIAKKIKLTAEAEELKPFFMKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSVLEGEKNNHRAKDLRAPPEQGKIFIARRSLLDELLEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGKFPTVVWTWWIMFLSTFSVPYFLFQHWATGYSKSSHPLIRSLFHGFLFMIFQIGVLGFGPTYVVLAYTLPPASRFIIIFEQIRFVMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLSFFYPVLFVLFMFFGMAFNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYARQHCPLKNPTFLDYVRPRSWTCRYVF
  
Inhibitor
Name:
BDBM50051885
Synonyms:
Benzyl-{4-[2-(4,5-diphenyl-1H-imidazol-2-yl)-5-methyl-[1,3]dioxan-5-yl]-butyl}-methyl-amine | CHEMBL287013
Type:
Small organic molecule
Emp. Form.:
C32H37N3O2
Mol. Mass.:
495.6551
SMILES:
CN(CCCCC1(C)COC(OC1)c1nc(c([nH]1)-c1ccccc1)-c1ccccc1)Cc1ccccc1 |(13.79,-10.45,;12.25,-10.45,;11.48,-11.8,;12.26,-13.13,;11.5,-14.46,;12.6,-15.56,;11.84,-16.9,;13.17,-17.67,;10.57,-17.32,;8.94,-16.7,;8.18,-18.05,;9.36,-17.63,;11.08,-18.24,;6.84,-17.29,;6.44,-15.79,;4.9,-15.72,;4.34,-17.16,;5.55,-18.12,;2.85,-17.56,;2.47,-19.05,;.99,-19.45,;-.11,-18.37,;.29,-16.88,;1.77,-16.47,;4.04,-14.43,;4.74,-13.06,;3.9,-11.77,;2.36,-11.85,;1.68,-13.23,;2.52,-14.51,;11.46,-9.12,;12.23,-7.8,;11.46,-6.47,;12.23,-5.13,;13.76,-5.11,;14.55,-6.46,;13.78,-7.8,)|
Structure:
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