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Target
Sterol O-acyltransferase 1
Ligand
BDBM50051892
Substrate
n/a
Meas. Tech.
ChEMBL_28658 (CHEMBL643993)
IC50
105±n/a nM
Citation
 Astles, PC; Ashton, MJ; Bridge, AW; Harris, NV; Hart, TW; Parrott, DP; Porter, B; Riddell, D; Smith, C; Williams, RJ Acyl-CoA:Cholesterol O-acyltransferase (ACAT) inhibitors. 2. 2-(1,3-Dioxan-2-yl)-4,5-diphenyl-1H-imidazoles as potent inhibitors of ACAT. J Med Chem 39:1423-32 (1996) [PubMed]  Article 
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACACT | ACACT1 | ACAT | ACAT1 | Acetyl-CoA acetyltransferase, mitochondrial | Acyl coenzyme A:cholesterol acyltransferase 1 | Acyl-CoA: cholesterol acyltransferase (ACAT) | Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) | Cholesterol acyltransferase 1 | SOAT | SOAT1 | SOAT1_HUMAN | STAT
Type:
Multi-pass membrane protein may form homo- or heterodimers.
Mol. Mass.:
64751.94
Organism:
Homo sapiens (Human)
Description:
P35610
Residue:
550
Sequence:
MVGEEKMSLRNRLSKSRENPEEDEDQRNPAKESLETPSNGRIDIKQLIAKKIKLTAEAEELKPFFMKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSVLEGEKNNHRAKDLRAPPEQGKIFIARRSLLDELLEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGKFPTVVWTWWIMFLSTFSVPYFLFQHWATGYSKSSHPLIRSLFHGFLFMIFQIGVLGFGPTYVVLAYTLPPASRFIIIFEQIRFVMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLSFFYPVLFVLFMFFGMAFNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYARQHCPLKNPTFLDYVRPRSWTCRYVF
  
Inhibitor
Name:
BDBM50051892
Synonyms:
1-{4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[1,3]dioxan-5-yl]-butyl}-4-pyridin-2-yl-piperazine | CHEMBL33127
Type:
Small organic molecule
Emp. Form.:
C33H39N5O2
Mol. Mass.:
537.6951
SMILES:
CC1(CCCCN2CCN(CC2)c2ccccn2)COC(OC1)c1nc(c([nH]1)-c1ccccc1)-c1ccccc1 |(17.65,-18.36,;16.32,-17.59,;16.29,-16.04,;14.99,-15.24,;15.03,-13.7,;13.72,-12.89,;13.75,-11.35,;12.44,-10.55,;12.49,-9.01,;13.84,-8.28,;15.17,-9.08,;15.12,-10.62,;13.91,-6.73,;12.58,-5.95,;12.61,-4.42,;13.95,-3.67,;15.27,-4.46,;15.24,-5.98,;15.05,-18.01,;13.42,-17.39,;12.65,-18.74,;13.84,-18.32,;15.55,-18.93,;11.3,-17.97,;10.9,-16.47,;9.36,-16.4,;8.8,-17.83,;10.02,-18.81,;7.33,-18.25,;6.24,-17.16,;4.74,-17.55,;4.35,-19.05,;5.46,-20.14,;6.94,-19.72,;8.52,-15.1,;9.22,-13.73,;8.38,-12.44,;6.84,-12.53,;6.14,-13.91,;6.98,-15.2,)|
Structure:
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