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Target
Sterol O-acyltransferase 1
Ligand
BDBM50051896
Substrate
n/a
Meas. Tech.
ChEMBL_28661 (CHEMBL643995)
IC50
300±n/a nM
Citation
 Astles, PC; Ashton, MJ; Bridge, AW; Harris, NV; Hart, TW; Parrott, DP; Porter, B; Riddell, D; Smith, C; Williams, RJ Acyl-CoA:Cholesterol O-acyltransferase (ACAT) inhibitors. 2. 2-(1,3-Dioxan-2-yl)-4,5-diphenyl-1H-imidazoles as potent inhibitors of ACAT. J Med Chem 39:1423-32 (1996) [PubMed]  Article 
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACACT | ACACT1 | ACAT | ACAT1 | Acetyl-CoA acetyltransferase, mitochondrial | Acyl coenzyme A:cholesterol acyltransferase 1 | Acyl-CoA: cholesterol acyltransferase (ACAT) | Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) | Cholesterol acyltransferase 1 | SOAT | SOAT1 | SOAT1_HUMAN | STAT
Type:
Multi-pass membrane protein may form homo- or heterodimers.
Mol. Mass.:
64751.94
Organism:
Homo sapiens (Human)
Description:
P35610
Residue:
550
Sequence:
MVGEEKMSLRNRLSKSRENPEEDEDQRNPAKESLETPSNGRIDIKQLIAKKIKLTAEAEELKPFFMKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSVLEGEKNNHRAKDLRAPPEQGKIFIARRSLLDELLEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGKFPTVVWTWWIMFLSTFSVPYFLFQHWATGYSKSSHPLIRSLFHGFLFMIFQIGVLGFGPTYVVLAYTLPPASRFIIIFEQIRFVMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLSFFYPVLFVLFMFFGMAFNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYARQHCPLKNPTFLDYVRPRSWTCRYVF
  
Inhibitor
Name:
BDBM50051896
Synonyms:
2-[5-(4-Benzyloxy-butyl)-5-methyl-[1,3]dioxan-2-yl]-4,5-diphenyl-1H-imidazole | CHEMBL284559
Type:
Small organic molecule
Emp. Form.:
C31H34N2O3
Mol. Mass.:
482.6133
SMILES:
CC1(CCCCOCc2ccccc2)COC(OC1)c1nc(c([nH]1)-c1ccccc1)-c1ccccc1 |(12.39,-15.53,;11.64,-14.2,;12.85,-13.25,;14.27,-13.77,;15.46,-12.79,;16.89,-13.32,;17.99,-12.23,;19.47,-12.62,;20.55,-11.53,;20.15,-10.05,;21.23,-8.95,;22.74,-9.34,;23.14,-10.83,;22.05,-11.92,;10.38,-14.62,;8.74,-14,;7.98,-15.35,;9.16,-14.93,;10.88,-15.54,;6.63,-14.58,;6.23,-13.09,;4.7,-13.02,;4.14,-14.46,;5.35,-15.42,;2.66,-14.86,;2.27,-16.35,;.79,-16.75,;-.32,-15.67,;.08,-14.18,;1.57,-13.77,;3.85,-11.73,;4.55,-10.35,;3.71,-9.07,;2.17,-9.15,;1.48,-10.53,;2.32,-11.81,)|
Structure:
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