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Target
Sterol O-acyltransferase 1
Ligand
BDBM50051906
Substrate
n/a
Meas. Tech.
ChEMBL_28658 (CHEMBL643993)
IC50
300±n/a nM
Citation
 Astles, PC; Ashton, MJ; Bridge, AW; Harris, NV; Hart, TW; Parrott, DP; Porter, B; Riddell, D; Smith, C; Williams, RJ Acyl-CoA:Cholesterol O-acyltransferase (ACAT) inhibitors. 2. 2-(1,3-Dioxan-2-yl)-4,5-diphenyl-1H-imidazoles as potent inhibitors of ACAT. J Med Chem 39:1423-32 (1996) [PubMed]  Article 
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACACT | ACACT1 | ACAT | ACAT1 | Acetyl-CoA acetyltransferase, mitochondrial | Acyl coenzyme A:cholesterol acyltransferase 1 | Acyl-CoA: cholesterol acyltransferase (ACAT) | Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) | Cholesterol acyltransferase 1 | SOAT | SOAT1 | SOAT1_HUMAN | STAT
Type:
Multi-pass membrane protein may form homo- or heterodimers.
Mol. Mass.:
64751.94
Organism:
Homo sapiens (Human)
Description:
P35610
Residue:
550
Sequence:
MVGEEKMSLRNRLSKSRENPEEDEDQRNPAKESLETPSNGRIDIKQLIAKKIKLTAEAEELKPFFMKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSVLEGEKNNHRAKDLRAPPEQGKIFIARRSLLDELLEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGKFPTVVWTWWIMFLSTFSVPYFLFQHWATGYSKSSHPLIRSLFHGFLFMIFQIGVLGFGPTYVVLAYTLPPASRFIIIFEQIRFVMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLSFFYPVLFVLFMFFGMAFNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYARQHCPLKNPTFLDYVRPRSWTCRYVF
  
Inhibitor
Name:
BDBM50051906
Synonyms:
4-{4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[1,3]dioxan-5-yl]-butyl}-morpholine | CHEMBL287233
Type:
Small organic molecule
Emp. Form.:
C28H35N3O3
Mol. Mass.:
461.5958
SMILES:
CC1(CCCCN2CCOCC2)COC(OC1)c1nc(c([nH]1)-c1ccccc1)-c1ccccc1 |(13.18,-17.69,;11.85,-16.92,;12.61,-15.57,;11.51,-14.47,;12.27,-13.14,;11.49,-11.81,;12.26,-10.46,;11.46,-9.13,;12.23,-7.8,;13.79,-7.79,;14.56,-9.13,;13.8,-10.46,;11.09,-18.25,;9.36,-17.65,;8.19,-18.07,;8.94,-16.71,;10.58,-17.34,;6.84,-17.3,;6.44,-15.8,;4.9,-15.73,;4.35,-17.17,;5.55,-18.14,;2.85,-17.58,;2.47,-19.06,;.99,-19.47,;-.11,-18.39,;.29,-16.89,;1.77,-16.48,;4.04,-14.44,;4.74,-13.07,;3.9,-11.78,;2.36,-11.86,;1.68,-13.24,;2.52,-14.52,)|
Structure:
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