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Target
Sterol O-acyltransferase 1
Ligand
BDBM50051904
Substrate
n/a
Meas. Tech.
ChEMBL_28658 (CHEMBL643993)
IC50
70±n/a nM
Citation
 Astles, PC; Ashton, MJ; Bridge, AW; Harris, NV; Hart, TW; Parrott, DP; Porter, B; Riddell, D; Smith, C; Williams, RJ Acyl-CoA:Cholesterol O-acyltransferase (ACAT) inhibitors. 2. 2-(1,3-Dioxan-2-yl)-4,5-diphenyl-1H-imidazoles as potent inhibitors of ACAT. J Med Chem 39:1423-32 (1996) [PubMed]  Article 
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACACT | ACACT1 | ACAT | ACAT1 | Acetyl-CoA acetyltransferase, mitochondrial | Acyl coenzyme A:cholesterol acyltransferase 1 | Acyl-CoA: cholesterol acyltransferase (ACAT) | Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) | Cholesterol acyltransferase 1 | SOAT | SOAT1 | SOAT1_HUMAN | STAT
Type:
Multi-pass membrane protein may form homo- or heterodimers.
Mol. Mass.:
64751.94
Organism:
Homo sapiens (Human)
Description:
P35610
Residue:
550
Sequence:
MVGEEKMSLRNRLSKSRENPEEDEDQRNPAKESLETPSNGRIDIKQLIAKKIKLTAEAEELKPFFMKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSVLEGEKNNHRAKDLRAPPEQGKIFIARRSLLDELLEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGKFPTVVWTWWIMFLSTFSVPYFLFQHWATGYSKSSHPLIRSLFHGFLFMIFQIGVLGFGPTYVVLAYTLPPASRFIIIFEQIRFVMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLSFFYPVLFVLFMFFGMAFNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYARQHCPLKNPTFLDYVRPRSWTCRYVF
  
Inhibitor
Name:
BDBM50051904
Synonyms:
4-{4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[1,3]dioxan-5-yl]-butyl}-thiomorpholine | CHEMBL286611
Type:
Small organic molecule
Emp. Form.:
C28H35N3O2S
Mol. Mass.:
477.661
SMILES:
CC1(CCCCN2CCSCC2)COC(OC1)c1nc(c([nH]1)-c1ccccc1)-c1ccccc1 |(14.14,-13.94,;12.81,-13.17,;13.21,-11.69,;12.13,-10.59,;12.54,-9.11,;11.46,-8.01,;11.88,-6.52,;10.79,-5.44,;11.21,-3.94,;12.7,-3.55,;13.77,-4.67,;13.35,-6.14,;11.53,-13.59,;9.9,-12.97,;9.15,-14.33,;10.32,-13.91,;12.05,-14.51,;7.8,-13.54,;7.4,-12.05,;5.86,-11.98,;5.3,-13.42,;6.51,-14.4,;3.81,-13.82,;3.43,-15.31,;1.94,-15.71,;.85,-14.64,;1.24,-13.14,;2.73,-12.74,;5,-10.69,;5.7,-9.32,;4.86,-8.03,;3.32,-8.1,;2.64,-9.5,;3.48,-10.78,)|
Structure:
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