Reaction Details Report a problem with these data
Target
Histamine H3 receptor
Ligand
BDBM50033042
Substrate
n/a
Meas. Tech.
ChEMBL_86909 (CHEMBL698419)
Ki
4.8±n/a nM
Citation
 Ganellin, CR; Fkyerat, A; Bang-Andersen, B; Athmani, S; Tertiuk, W; Garbarg, M; Ligneau, X; Schwartz, JC A novel series of (phenoxyalkyl)imidazoles as potent H3-receptor histamine antagonists. J Med Chem 39:3806-13 (1996) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50033042
Synonyms:
2-[2-(1H-Imidazol-4-yl)-ethylsulfanyl]-5-nitro-pyridine | CHEMBL112504
Type:
Small organic molecule
Emp. Form.:
C10H10N4O2S
Mol. Mass.:
250.277
SMILES:
[O-][N+](=O)c1ccc(SCCc2cnc[nH]2)nc1
Structure:
Search PDB for entries with ligand similarity: