Reaction Details Report a problem with these data
Target
Dual specificity mitogen-activated protein kinase kinase 7
Ligand
BDBM50543
Substrate
n/a
Meas. Tech.
ChEMBL_1814595 (CHEMBL4314169)
Kd
1900±n/a nM
Citation
 Schepetkin, IA; Karpenko, AS; Khlebnikov, AI; Shibinska, MO; Levandovskiy, IA; Kirpotina, LN; Danilenko, NV; Quinn, MT Synthesis, anticancer activity, and molecular modeling of 1,4-naphthoquinones that inhibit MKK7 and Cdc25. Eur J Med Chem 183:0 (2019) [PubMed]  Article 
Target
Name:
Dual specificity mitogen-activated protein kinase kinase 7
Synonyms:
Dual specificity mitogen-activated protein kinase kinase 7 | Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7) | JNKK2 | MAP2K7 | MEK7 | MKK7 | MP2K7_HUMAN | PRKMK7 | SKK4
Type:
Protein
Mol. Mass.:
47502.52
Organism:
Homo sapiens (Human)
Description:
O14733
Residue:
419
Sequence:
MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFFR
  
Inhibitor
Name:
BDBM50543
Synonyms:
3-[(3-chloro-1,4-diketo-2-naphthyl)amino]benzoic acid | 3-[(3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)amino]benzoic acid | 3-[(3-chloro-1,4-dioxo-2-naphthalenyl)amino]benzoic acid | 3-[(3-chloro-1,4-dioxonaphthalen-2-yl)amino]benzoic acid | 3-[[3-chloranyl-1,4-bis(oxidanylidene)naphthalen-2-yl]amino]benzoic acid | MLS000689606 | SMR000312850 | cid_470958
Type:
Small organic molecule
Emp. Form.:
C17H10ClNO4
Mol. Mass.:
327.719
SMILES:
OC(=O)c1cccc(NC2=C(Cl)C(=O)c3ccccc3C2=O)c1 |c:9|
Structure:
Search PDB for entries with ligand similarity: