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Target
M-phase inducer phosphatase 1
Ligand
BDBM50012070
Substrate
n/a
Meas. Tech.
ChEMBL_1814594 (CHEMBL4314168)
IC50
700±n/a nM
Citation
 Schepetkin, IA; Karpenko, AS; Khlebnikov, AI; Shibinska, MO; Levandovskiy, IA; Kirpotina, LN; Danilenko, NV; Quinn, MT Synthesis, anticancer activity, and molecular modeling of 1,4-naphthoquinones that inhibit MKK7 and Cdc25. Eur J Med Chem 183:0 (2019) [PubMed]  Article 
Target
Name:
M-phase inducer phosphatase 1
Synonyms:
CDC25A | Dual specificity phosphatase (Cdc25A) | Dual specificity phosphatase Cdc25A | M-phase inducer phosphatase 1 | MPIP1_HUMAN | phosphatase Cdc25
Type:
Protein
Mol. Mass.:
59090.18
Organism:
Homo sapiens (Human)
Description:
P30304
Residue:
524
Sequence:
MELGPEPPHRRRLLFACSPPPASQPVVKALFGASAAGGLSPVTNLTVTMDQLQGLGSDYEQPLEVKNNSNLQRMGSSESTDSGFCLDSPGPLDSKENLENPMRRIHSLPQKLLGCSPALKRSHSDSLDHDIFQLIDPDENKENEAFEFKKPVRPVSRGCLHSHGLQEGKDLFTQRQNSAPARMLSSNERDSSEPGNFIPLFTPQSPVTATLSDEDDGFVDLLDGENLKNEEETPSCMASLWTAPLVMRTTNLDNRCKLFDSPSLCSSSTRSVLKRPERSQEESPPGSTKRRKSMSGASPKESTNPEKAHETLHQSLSLASSPKGTIENILDNDPRDLIGDFSKGYLFHTVAGKHQDLKYISPEIMASVLNGKFANLIKEFVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLLKKPIVPTDGKRVIVVFHCEFSSERGPRMCRYVRERDRLGNEYPKLHYPELYVLKGGYKEFFMKCQSYCEPPSYRPMHHEDFKEDLKKFRTKSRTWAGEKSKREMYSRLKKL
  
Inhibitor
Name:
BDBM50012070
Synonyms:
5-Hydroxy-2-methyl-[1,4]naphthoquinone | 5-hydroxy-2-methylnaphthalene-1,4-dione | CHEMBL295316 | Plum-bagin | Plumbagin (6b) | Pumbagin | plumbagin
Type:
Small organic molecule
Emp. Form.:
C11H8O3
Mol. Mass.:
188.1794
SMILES:
CC1=CC(=O)c2c(O)cccc2C1=O |t:1|
Structure:
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