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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50505083
Substrate
n/a
Meas. Tech.
ChEMBL_1821275 (CHEMBL4320935)
IC50
72±n/a nM
Citation
 Agnetta, L; Bermudez, M; Riefolo, F; Matera, C; Claro, E; Messerer, R; Littmann, T; Wolber, G; Holzgrabe, U; Decker, M Fluorination of Photoswitchable Muscarinic Agonists Tunes Receptor Pharmacology and Photochromic Properties. J Med Chem 62:3009-3020 (2019) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50505083
Synonyms:
CHEMBL4436277
Type:
Small organic molecule
Emp. Form.:
C22H21BrF4N4O2
Mol. Mass.:
529.325
SMILES:
[Br-].C[N+](C)(CC#CCOC1=NOCC1)Cc1cc(F)c(\N=N/c2c(F)cccc2F)c(F)c1 |t:8|
Structure:
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