Reaction Details Report a problem with these data
Target
Potassium channel subfamily K member 3
Ligand
BDBM50350790
Substrate
n/a
Meas. Tech.
ChEMBL_1822417 (CHEMBL4322181)
IC50
41000±n/a nM
Citation
 Bedoya, M; Rinné, S; Kiper, AK; Decher, N; González, W; Ramírez, D TASK Channels Pharmacology: New Challenges in Drug Design. J Med Chem 62:10044-10058 (2019) [PubMed]  Article 
Target
Name:
Potassium channel subfamily K member 3
Synonyms:
Acid-sensitive potassium channel protein TASK-1 | KCNK3_RAT | Kcnk3 | Potassium channel subfamily K member 3 | TWIK-related acid-sensitive K(+) channel 1 | Task | Task1 | Two pore K(+) channel KT3.1 | Two pore potassium channel KT3.1
Type:
PROTEIN
Mol. Mass.:
45290.45
Organism:
Rattus norvegicus
Description:
ChEMBL_100112
Residue:
411
Sequence:
MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPEMIERQRLELRQLELRARYNLSEGGYEELERVVLRLKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMFYALLGIPLTLVMFQSLGERINTFVRYLLHRAKRGLGMRHAEVSMANMVLIGFVSCISTLCIGAAAFSYYERWTFFQAYYYCFITLTTIGFGDYVALQKDQALQTQPQYVAFSFVYILTGLTVIGAFLNLVVLRFMTMNAEDEKRDAEHRALLTHNGQAGGLGGLSCLSGSLGDGVRPRDPVTCAAAAGGMGVGVGVGGSGFRNVYAEMLHFQSMCSCLWYKSREKLQYSIPMIIPRDLSTSDTCVEHSHSSPGGGGRYSDTPSHPCLCSGTQRSAISSVSTGLHSLATFRGLMKRRSSV
  
Inhibitor
Name:
BDBM50350790
Synonyms:
BUPIVACAINE HYDROCHLORIDE | Bupivacaine | SAMPL3, G1
Type:
Small organic molecule
Emp. Form.:
C18H28N2O
Mol. Mass.:
288.4277
SMILES:
CCCCN1CCCCC1C(=O)Nc1c(C)cccc1C
Structure:
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