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Target
NAD-dependent protein deacetylase sirtuin-2
Ligand
BDBM50505497
Substrate
n/a
Meas. Tech.
ChEMBL_1822882 (CHEMBL4322646)
IC50
21500±n/a nM
Citation
 Monaldi, D; Rotili, D; Lancelot, J; Marek, M; Wössner, N; Lucidi, A; Tomaselli, D; Ramos-Morales, E; Romier, C; Pierce, RJ; Mai, A; Jung, M Structure-Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from  J Med Chem 62:8733-8759 (2019) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacetylase sirtuin-2
Synonyms:
NAD-Dependent Deacetylase Sirtuin-2 | NAD-dependent deacetylase sirtuin 2 | NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-2 (SIRT2) | SIR2-like | SIR2-like protein 2 | SIR2L | SIR2L2 | SIR2_HUMAN | SIRT2 | Sirtuin 2 (SIRT2)
Type:
Hydrolase
Mol. Mass.:
43172.62
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
389
Sequence:
MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGVPNPSTSASPKKSPPPAKDEARTTEREKPQ
  
Inhibitor
Name:
BDBM50505497
Synonyms:
CHEMBL4444104
Type:
Small organic molecule
Emp. Form.:
C28H27N7O2S
Mol. Mass.:
525.625
SMILES:
COc1cc(OC)cc(Sc2ccc(cc2)C(N(C)c2ncc3c(N)nc(N)nc3n2)c2ccccc2)c1
Structure:
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