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Target
Lysyl oxidase homolog 2
Ligand
BDBM50505661
Substrate
n/a
Meas. Tech.
ChEMBL_1823505 (CHEMBL4323269)
IC50
63±n/a nM
Citation
 Findlay, AD; Foot, JS; Buson, A; Deodhar, M; Jarnicki, AG; Hansbro, PM; Liu, G; Schilter, H; Turner, CI; Zhou, W; Jarolimek, W Identification and Optimization of Mechanism-Based Fluoroallylamine Inhibitors of Lysyl Oxidase-like 2/3. J Med Chem 62:9874-9889 (2019) [PubMed]  Article 
Target
Name:
Lysyl oxidase homolog 2
Synonyms:
1.4.3.13 | LOXL2 | LOXL2_HUMAN | Lysyl oxidase homolog 2 | Lysyl oxidase-like protein 2 | Lysyl oxidase-related protein 2 | Lysyl oxidase-related protein WS9-14
Type:
PROTEIN
Mol. Mass.:
86721.38
Organism:
Homo sapiens (Human)
Description:
ChEMBL_115990
Residue:
774
Sequence:
MERPLCSHLCSCLAMLALLSPLSLAQYDSWPHYPEYFQQPAPEYHQPQAPANVAKIQLRLAGQKRKHSEGRVEVYYDGQWGTVCDDDFSIHAAHVVCRELGYVEAKSWTASSSYGKGEGPIWLDNLHCTGNEATLAACTSNGWGVTDCKHTEDVGVVCSDKRIPGFKFDNSLINQIENLNIQVEDIRIRAILSTYRKRTPVMEGYVEVKEGKTWKQICDKHWTAKNSRVVCGMFGFPGERTYNTKVYKMFASRRKQRYWPFSMDCTGTEAHISSCKLGPQVSLDPMKNVTCENGLPAVVSCVPGQVFSPDGPSRFRKAYKPEQPLVRLRGGAYIGEGRVEVLKNGEWGTVCDDKWDLVSASVVCRELGFGSAKEAVTGSRLGQGIGPIHLNEIQCTGNEKSIIDCKFNAESQGCNHEEDAGVRCNTPAMGLQKKLRLNGGRNPYEGRVEVLVERNGSLVWGMVCGQNWGIVEAMVVCRQLGLGFASNAFQETWYWHGDVNSNKVVMSGVKCSGTELSLAHCRHDGEDVACPQGGVQYGAGVACSETAPDLVLNAEMVQQTTYLEDRPMFMLQCAMEENCLSASAAQTDPTTGYRRLLRFSSQIHNNGQSDFRPKNGRHAWIWHDCHRHYHSMEVFTHYDLLNLNGTKVAEGHKASFCLEDTECEGDIQKNYECANFGDQGITMGCWDMYRHDIDCQWVDITDVPPGDYLFQVVINPNFEVAESDYSNNIMKCRSRYDGHRIWMYNCHIGGSFSEETEKKFEHFSGLLNNQLSPQ
  
Inhibitor
Name:
BDBM50505661
Synonyms:
CHEMBL4574820
Type:
Small organic molecule
Emp. Form.:
C24H30ClFN4O3S
Mol. Mass.:
509.036
SMILES:
Cl.CN(C)C(=O)c1ccc2c(c(C)n(C\C(F)=C\CN)c2c1)-c1cccc(c1)S(=O)(=O)N(C)C
Structure:
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