Reaction Details Report a problem with these data
Target
cAMP-dependent protein kinase
Ligand
BDBM6760
Substrate
n/a
Meas. Tech.
ChEMBL_161879 (CHEMBL770262)
IC50
0.016000±n/a nM
Citation
Kaneko, M; Saito, Y; Saito, H; Matsumoto, T; Matsuda, Y; Vaught, JL; Dionne, CA; Angeles, TS; Glicksman, MA; Neff, NT; Rotella, DP; Kauer, JC; Mallamo, JP; Hudkins, RL; Murakata, C Neurotrophic 3,9-bis[(alkylthio)methyl]-and-bis(alkoxymethyl)-K-252a derivatives. J Med Chem 40:1863-9 (1997) [PubMed] Article
More Info.:
Target
Name:
cAMP-dependent protein kinase
Synonyms:
Cyclic AMP-dependent protein kinase (PKA) | PKA catalytic subunit alpha | Serine/threonine-protein kinase | cAMP-dependent protein kinase alpha-catalytic subunit
Type:
Enzyme
Mol. Mass.:
40766.33
Organism:
Oryctolagus cuniculus (Rabbit)
Description:
Q95J97
Residue:
351
Sequence:
MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAQLDQFERIKTLGTGSFGRVMLSKHKETGNHYAMKILDKQKVVKLKQIEHTLNVKRILQAVNFPFLVKLEFSFKENSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQQTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAADYPPFFADQPIQIYEKIVYGKVRFPSHFSSDLKDLLRNLQQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF
Inhibitor
Name:
BDBM6760
Synonyms:
(+)-K-252a | CHEMBL281948 | K-252a | methyl (15S,16R,18R)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0^{2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]octacosa-1(26),2(6),7(27),8(13),9,11,20(25),21,23-nonaene-16-carboxylate
Type:
Small organic molecule
Emp. Form.:
C27H21N3O5
Mol. Mass.:
467.4727
SMILES:
COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|