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Target
Reverse transcriptase/RNaseH
Ligand
BDBM50059015
Substrate
n/a
Meas. Tech.
ChEMBL_197284 (CHEMBL804271)
EC50
9000±n/a nM
Citation
 Winter, H; Maeda, Y; Uchida, H; Mitsuya, H; Zemlicka, J Phosphodiester amidates of unsaturated nucleoside analogues: synthesis and anti-HIV activity. J Med Chem 40:2191-5 (1997) [PubMed]  Article 
Target
Name:
Reverse transcriptase/RNaseH
Synonyms:
HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH
Type:
PROTEIN
Mol. Mass.:
65229.15
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_1473730
Residue:
566
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKVLFLDGID
  
Inhibitor
Name:
BDBM50059015
Synonyms:
CHEMBL69158 | [(E)-5-(6-Amino-purin-9-yl)-pent-3-enyloxymethyl]-phosphonic acid
Type:
Small organic molecule
Emp. Form.:
C11H16N5O4P
Mol. Mass.:
313.2496
SMILES:
Nc1ncnc2n(C\C=C\CCOCP(O)(O)=O)cnc12
Structure:
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