Reaction Details Report a problem with these data
Target
Nuclear receptor ROR-alpha
Ligand
BDBM50509338
Substrate
n/a
Meas. Tech.
ChEMBL_1837937 (CHEMBL4338070)
IC50
>10000±n/a nM
Citation
Marcoux, D; Duan, JJ; Shi, Q; Cherney, RJ; Srivastava, AS; Cornelius, L; Batt, DG; Liu, Q; Beaudoin-Bertrand, M; Weigelt, CA; Khandelwal, P; Vishwakrishnan, S; Selvakumar, K; Karmakar, A; Gupta, AK; Basha, M; Ramlingam, S; Manjunath, N; Vanteru, S; Karmakar, S; Maddala, N; Vetrichelvan, M; Gupta, A; Rampulla, RA; Mathur, A; Yip, S; Li, P; Wu, DR; Khan, J; Ruzanov, M; Sack, JS; Wang, J; Yarde, M; Cvijic, ME; Li, S; Shuster, DJ; Borowski, V; Xie, JH; McIntyre, KW; Obermeier, MT; Fura, A; Stefanski, K; Cornelius, G; Hynes, J; Tino, JA; Macor, JE; Salter-Cid, L; Denton, R; Zhao, Q; Carter, PH; Dhar, TGM Rationally Designed, Conformationally Constrained Inverse Agonists of ROR?t-Identification of a Potent, Selective Series with Biologic-Like in Vivo Efficacy. J Med Chem 62:9931-9946 (2019) [PubMed] Article
More Info.:
Target
Name:
Nuclear receptor ROR-alpha
Synonyms:
NR1F1 | Nuclear receptor RZR-alpha | Nuclear receptor subfamily 1 group F member 1 | RAR-related orphan receptor A | RORA | RORA_HUMAN | RZRA | Retinoid-related orphan receptor-alpha
Type:
PROTEIN
Mol. Mass.:
58976.26
Organism:
Homo sapiens (Human)
Description:
ChEMBL_101591
Residue:
523
Sequence:
MESAPAAPDPAASEPGSSGADAAAGSRETPLNQESARKSEPPAPVRRQSYSSTSRGISVTKKTHTSQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG
Inhibitor
Name:
BDBM50509338
Synonyms:
CHEMBL4457990
Type:
Small organic molecule
Emp. Form.:
C31H32F8N2O5S
Mol. Mass.:
696.648
SMILES:
[H][C@@]12CN(CCC)c3cc(ccc3[C@@]1(CCN2C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F |r,wU:19.21,wD:22.28,1.0,13.31,(13.85,-27.45,;12.52,-28.23,;12.53,-26.67,;11.18,-25.89,;11.18,-24.35,;12.51,-23.58,;12.51,-22.04,;9.84,-26.67,;8.5,-25.91,;7.18,-26.68,;7.17,-28.22,;8.51,-28.99,;9.84,-28.22,;11.17,-29,;11.49,-30.52,;13.03,-30.69,;13.67,-29.28,;15.18,-28.96,;15.67,-27.5,;16.21,-30.11,;17.7,-29.8,;18.73,-30.94,;18.24,-32.41,;16.73,-32.72,;15.71,-31.57,;19.27,-33.56,;18.79,-35.02,;20.78,-33.25,;10.07,-30.08,;8.98,-31.17,;8.58,-29.68,;10.46,-31.57,;9.36,-32.65,;9.75,-34.14,;11.23,-34.55,;11.62,-36.04,;12.33,-33.46,;11.94,-31.98,;5.84,-25.91,;4.5,-25.14,;4.51,-26.68,;3.17,-25.91,;4.51,-28.22,;3.17,-27.44,;5.84,-24.37,;7.18,-23.6,;4.51,-23.6,;5.83,-22.83,)|