TargetTGF-beta receptor type-1(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Development
Curated by ChEMBL
Affinity DataKi: 0.800nMAssay Description:Inhibition of TGFBR1 in human whole blood assessed as apparent inhibition constant by measuring reduction in TGFbeta-induced SMAD phosphorylationMore data for this Ligand-Target Pair
TargetTGF-beta receptor type-1(Mus musculus)
Bristol-Myers Squibb Research & Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Development
Curated by ChEMBL
Affinity DataKi: 1.40nMAssay Description:Inhibition of TGFBR1 in mouse whole blood assessed as apparent inhibition constant by measuring reduction in TGFbeta-induced SMAD phosphorylationMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of GST-Xa tagged human AAK1 (30 to 330 residues) expresssed in bacteria using (5-FAM)-Aha-KEEQSQITSQVTGQIGWR-NH2 peptide as substrate incu...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of GST-Xa tagged human AAK1 (30 to 330 residues) expresssed in bacteria using (5-FAM)-Aha-KEEQSQITSQVTGQIGWR-NH2 peptide as substrate incu...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of GST-Xa tagged human AAK1 (30 to 330 residues) expresssed in bacteria using (5-FAM)-Aha-KEEQSQITSQVTGQIGWR-NH2 peptide as substrate incu...More data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of GST-Xa tagged human AAK1 (30 to 330 residues) expresssed in bacteria using (5-FAM)-Aha-KEEQSQITSQVTGQIGWR-NH2 peptide as substrate incu...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of GST-Xa tagged human AAK1 (30 to 330 residues) expresssed in bacteria using (5-FAM)-Aha-KEEQSQITSQVTGQIGWR-NH2 peptide as substrate incu...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.630nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.700nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.700nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Development
Curated by ChEMBL
Affinity DataIC50: 0.700nMAssay Description:Inhibition of His-tagged TGFBR1 kinase domain T204D mutant (unknown origin) incubated for 1 hr by HTRF analysisMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.700nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Inhibition of GST-Xa tagged human AAK1 (30 to 330 residues) expresssed in bacteria using (5-FAM)-Aha-KEEQSQITSQVTGQIGWR-NH2 peptide as substrate incu...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of AKK1 in HEK293F cells assessed as reduction in phospho mu2 formation incubated for 3 hrs by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of GST-Xa tagged human AAK1 (30 to 330 residues) expresssed in bacteria using (5-FAM)-Aha-KEEQSQITSQVTGQIGWR-NH2 peptide as substrate incu...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:Inhibition of GST-Xa tagged human AAK1 (30 to 330 residues) expresssed in bacteria using (5-FAM)-Aha-KEEQSQITSQVTGQIGWR-NH2 peptide as substrate incu...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 0.900nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Development
Curated by ChEMBL
Affinity DataIC50: 0.900nMAssay Description:Inhibition of His-tagged TGFBR1 kinase domain T204D mutant (unknown origin) incubated for 1 hr by HTRF analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:Inhibition of AKK1 in HEK293F cells assessed as reduction in phospho mu2 formation incubated for 3 hrs by Western blot analysisMore data for this Ligand-Target Pair
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Development
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of His-tagged TGFBR1 kinase domain T204D mutant (unknown origin) incubated for 1 hr by HTRF analysisMore data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Early Development
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Antagonist activity at full length human PAR4 expressed in HEK293 cells assessed as reduction in H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-Lys-Asn-Gly-NH2 i...More data for this Ligand-Target Pair