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Target
Gastrin/cholecystokinin type B receptor
Ligand
BDBM50063640
Substrate
n/a
Meas. Tech.
ChEMBL_48248 (CHEMBL661838)
IC50
1.2±n/a nM
Citation
 Padia, JK; Field, M; Hinton, J; Meecham, K; Pablo, J; Pinnock, R; Roth, BD; Singh, L; Suman-Chauhan, N; Trivedi, BK; Webdale, L Novel nonpeptide CCK-B antagonists: design and development of quinazolinone derivatives as potent, selective, and orally active CCK-B antagonists. J Med Chem 41:1042-9 (1998) [PubMed]  Article 
Target
Name:
Gastrin/cholecystokinin type B receptor
Synonyms:
Cckbr | Cholecystokinin A | Cholecystokinin receptor | GASR_MOUSE | Gastrin/cholecystokinin type B receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49196.59
Organism:
MOUSE
Description:
Cholecystokinin A CCKBR MOUSE::P56481
Residue:
453
Sequence:
MDLLKLNRSLQGPGPGSGSSLCRPGVSLLNSSSAGNLSCETPRIRGTGTRELELTIRITLYAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLNLAAIALERYSAICRPLQARVWQTRSHAARVILATWLLSGLLMVPYPVYTVVQPVGPRILQCMHLWPSERVQQMWSVLLLILLFFIPGVVMAVAYGLISRELYLGLRFDGDNDSETQSRVRNQGGLPGGAAAPGPVHQNGGCRHVTSLTGEDSDGCYVQLPRSRLEMTTLTTPTTGPGPGPRPNQAKLLAKKRVVRMLLVIVLLFFVCWLPVYSANTWRAFDGPGARRALAGAPISFIHLLSYTSACANPLVYCFMHRRFRQACLDTCARCCPRPPRARPRPLPDEDPPTPSIASLSRLSYTTISTLGPG
  
Inhibitor
Name:
BDBM50063640
Synonyms:
CHEMBL9405 | N-(3-cyanobenzene)-2-[3,4-dihydro-3-[3-(1-methylethoxy)phenyl]-4-oxo-2-quinazolinyl]hydrazinecarboxamide
Type:
Small organic molecule
Emp. Form.:
C25H22N6O3
Mol. Mass.:
454.4806
SMILES:
CC(C)Oc1cccc(c1)-n1c(NNC(=O)Nc2cccc(c2)C#N)nc2ccccc2c1=O
Structure:
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