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Target
Proto-oncogene tyrosine-protein kinase Src
Ligand
BDBM50064347
Substrate
n/a
Meas. Tech.
ChEMBL_216860 (CHEMBL816697)
IC50
>10000±n/a nM
Citation
 Trumpp-Kallmeyer, S; Rubin, JR; Humblet, C; Hamby, JM; Hollis Showalter, HD Development of a binding model to protein tyrosine kinases for substituted pyrido[2,3-d]pyrimidine inhibitors. J Med Chem 41:1752-63 (1998) [PubMed]  Article 
Target
Name:
Proto-oncogene tyrosine-protein kinase Src
Synonyms:
Proto-oncogene c-Src | SRC | SRC_CHICK | Tyrosine-protein kinase SRC | c-Src | p60-Src | p60c-src | pp60c-src
Type:
Tyr protein kinase
Mol. Mass.:
60015.36
Organism:
Gallus gallus (Chicken)
Description:
P00523
Residue:
533
Sequence:
MGSSKSKPKDPSQRRRSLEPPDSTHHGGFPASQTPNKTAAPDTHRTPSRSFGTVATEPKLFGGFNTSDTVTSPQRAGALAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLTTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNPENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFSSLQQLVAYYSKHADGLCHRLTNVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
  
Inhibitor
Name:
BDBM50064347
Synonyms:
6-(2,6-Dichloro-phenyl)-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one | 6-(2,6-dichlorophenyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one | CHEMBL50977
Type:
Small organic molecule
Emp. Form.:
C14H9Cl2N3O
Mol. Mass.:
306.147
SMILES:
Cn1c2ncncc2cc(-c2c(Cl)cccc2Cl)c1=O |(4.31,-8.43,;4.32,-6.89,;2.98,-6.1,;1.65,-6.89,;.32,-6.12,;.32,-4.57,;1.65,-3.79,;2.99,-4.57,;4.32,-3.79,;5.66,-4.57,;6.99,-3.81,;6.99,-2.28,;5.66,-1.5,;8.32,-1.5,;9.67,-2.28,;9.65,-3.82,;8.32,-4.59,;8.32,-6.12,;5.66,-6.12,;6.99,-6.89,)|
Structure:
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